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(TMZ) - Nyong'o's now-famous Oscar dress -- adorned in pearls -- was stolen right out of her hotel room ... TMZ has learned.

Law enforcement sources tell TMZ ... the dress was taken out of Lupita's room at The London West Hollywood. The gown is made of pearls ... 6,000 white Akoya pearls. It's valued at $150,000.

Sournces tell TMZ that Lupita told cops it was taken from her room sometime between 8 AM and 9 PM Tuesday ... while she was gone.  

TMZ is told there is security footage that cops are looking at that could catch the culprit right in the act. 

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