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Proto: Dispatches from the Frontiers of Medicine

Proto: Dispatches from the Frontiers of Medicine

  • Proto: Dispatches from the Frontiers of Medicine
  • Join us for insights into breakthroughs in clinical medicine, research, and health policy, and innov...

Episodes

Evidence-Based Medicine

Hosted by: Bruce Bloom Guest: Steven Pearson Evidence-based medicine is a movement that assumes care will be better, safer, and more cost-efficient when physicians base clinical judgments on solid empirical science instead of clinical observation and experience. But who creates such guidelines, how good is the evidence underlying them— and wh...

November 5, 2012 | 15 min

Repurposing Drugs

Hosted by: Bruce Bloom Guests: Frances Toneguzzo, David Borsook The discovery of a new use for a failed or existing drug has often been entirely serendipitous: A drug in development to treat angina failed, but became famous as Viagra when some of the test subjects reported interesting side effects. There are other notable examples, and now scientis...

February 20, 2012 | 15 min

Love It or Hate It: Changing Evidence Regarding Hormone Therapy

Hosted by: Bruce Bloom Guest: Isaac Schiff In the 80-year history of hormone therapy, it has been alternately embraced and rejected. Case in point: the original term, hormone replacement therapy, came to be seen as highlighting a negative state, and was changed to simply hormone therapy. Why has the pendulum swung so frequently back and f...

February 13, 2012 | 15 min

When the Drug Fits: Examining Targeted Cancer Therapy

Hosted by: Bruce Bloom Guest: David Fisher Imatinib mesylate was initially approved for chronic myeloid leukemia. It has also been used against gastrointestinal cancer and melanoma. What are the implications of broadening the application of this targeted cancer drug for the way that cancers are diagnosed and classified, and what will the impact be ...

February 6, 2012 | 15 min

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