Tech on Drugs with Shai Shen-Orr

Tech on Drugs with Shai Shen-Orr

In a big-data age, drug development needs to be reinvented. The data revolution is already taking place in finance and commerce, in agriculture and transportation. There’s no reason for pharma to stay behind. “Tech on Drugs” is a podcast about the future of pharma. From novel targets to novel biomarkers. From disease models to population models. From clinical trials to synthetic trials. It’s a show about the doctor in the clinic who needs to build on molecular features and about the bioinformatician in the lab who needs to build on clinical endpoints. In each episode, our host, Prof. Shai Shen-Orr, gets to do what he loves to do most. He gets to speak with some of the world’s top scientists and healthcare executives about the industry's digital transformation.

Episodes

May 11, 2025 61 mins
We’re kicking off Season 3 of Tech on Drugs with Prof. Nir Hacohen — Director of the Center for Cancer Research at MGH, founding director of the Broad Institute’s Cell Circuits Program, and a distinguished member of CytoReason's Science Advisory Board.

Shai and Nir cover everything from the rise of antibodies and the promise (and pitfalls) of STING agonists, to the future of personalized cancer vaccines and a mysterious immune cell ...
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Tom Bumol's career spans major roles at Eli Lilly, the Allen Institute, and beyond. He is also a distinguished member of CytoReason's Science Advisory Board.In this episode, Tom shares insights into drug development's successes, failures, and future direction, including:
  • Lessons from lupus - the story of a failed lupus trial that revealed the critical importance of understanding disease heterogeneity and inspired new approaches ...
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October 14, 2024 30 mins
This episode was recorded in the beautiful Island of Crete, at CytoReason's employee conference, the CytoSummit.

CytoReason's Co-founder Shai Shen-Orr hosts AION Labs CTO Yair Benita. 

Yair is a computational biologist who spent more than 20 years studying biology through omics and clinical data in an effort to piece together mechanisms of human disease. He’s been leading computational teams in drug discovery at CytoReason, Compugen,...
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While most neuroimmunologists try to understand how the immune system affects the brain, Prof. Asya Rolls has taken the road less traveled in her lab at the Technion. She and her team try to understand how the brain affects the immune system. 

In this episode of Tech on Drugs, Asya and Shai talked about the power of placebo and how brain activity, particularly in the reward system, can influence the immune system. 

They discussed the...
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This one was fun.

In the latest episode of Tech on Drugs, Shai met with Prof. Eran Segal from the Weizmann Institute of Science.

Eran heads a multidisciplinary team of computational biologists and experimental scientists working in the area of Computational and Systems biology. His lab at Weizmann aims to develop personalized nutrition and personalized medicine using machine learning, computational biology, probabilistic modeling, an...
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September 28, 2023 28 mins
Our guest this time was Prof. Ido Amit, whose lab at the Weizmann Institute of Science pioneered single cell transcriptomic analysis and its application to the immune system.

Amit’s research focuses on some of the most important questions in immunology – specifically those relevant to novel targets for immunotherapy in autoimmune diseases, neurodegeneration, and cancer.

A fascinating discussion between two leading scientists about th...
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What will the future of precision medicine look like 5-10 years down the line? And how will AI accelerate this future?

I asked Dr. Emanuele de Rinaldis to answer this and many other questions.

Emanuele is VP, Global Head of Precision Medicine & Computational Biology at Sanofi R&D.

He believes that AI will help us define new taxonomies of diseases. We will identify different types of Asthma, different types of Fibrosis.

And AI...
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Our guest this time is serial biotech entrepreneur Yanay Ofran. Yanay is a renowned computational biophysicist and the CEO and Co-founder of Biolojic Design. More importantly, Yanay, together with his stellar team, developed the first AI-designed antibody. He shared with Shai his (strong) opinions about:
  • The barriers to precision medicine (and how to overcome them).
  • The potential of AI-designed antibodies (and how, just a few we...
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The doctor in the clinic must build on molecular features and the bioinformatician in the lab must build on data from the clinic. Prof. Yehuda Chowers, a leading gastroenterologist, has been harping on this point for years. It's a two-way street that will benefit both drug makers and drug consumers. In this episode of TOD, Chowers talks to host Shai Shen-Orr about immunogenicity, clinical trials, and population models.
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January 16, 2023 28 mins
Our first episode features world renowned epidemiologist, Prof. Ran Balicer, Chief Innovation Officer at Clalit Health Services, Israel’s largest healthcare organization. We talked about the mining of real-world data and how it guides healthcare policy. The impact on Covid is pretty mind-boggling!












































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January 12, 2023 44 secs
This is a podcast about the future of pharma. From novel targets to novel biomarkers. From disease models to population models. From clinical trials to synthetic trials. In each episode, our host Prof. Shai Shen-Orr talks to world-leading scientists and healthcare executives about the future of pharma.
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