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March 25, 2026 48 mins

Despite the popularity, there is an ugly side to GLP-1’s. 

Dr. Dubrow and Dr. Schwartz are back with a buyer beware message for GLP-1 users. 

Hear how it may be linked to an eating disorder, and an FYI about your BMI you have to hear!

See omnystudio.com/listener for privacy information.

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Episode Transcript

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Speaker 1 (00:04):
Welcome to another episode of Between Us Doctors. I'm doctor
Terry bro I'm doctor Robert Schor. Okay, listen, rob I
want to talk to you about something that's been disturbing
me for the last two weeks. Ever since I watched
the oscars, I realized that there's like a new epidemic
in this world. And you know what it is.

Speaker 2 (00:27):
What's the epidemic?

Speaker 1 (00:28):
Anarexia ozempica. I kid you not. It's like medically induced
appetite suppression. It's like chemical starvation. People are taking these
GLP one drugs to the next level, and it's like
a very significant misuse. It's almost like enabling an eating disorder.

(00:53):
Have you noticed this in your patience?

Speaker 2 (00:56):
Yeah, it's a it's a I'm noticing it not only
in my painations, but all over society and people that
I know. It's it's taking it's basically now making biochemical
eating disorder possible. Yeah, it's I mean, it's it's taking
it beyond weight loss to drug induced malnutrition.

Speaker 1 (01:17):
Yeah, anorexia ozampica. Let's let's let's talk about what it's not.
This is not anorexia nervosa. This is not a psychiatric disorder.
This is a medically induced eating disorder that I think
is a giant problem that I'm seeing article after article,

(01:37):
podcast after podcasts about celebrities talking about how they're misusing
these drugs and they don't have any medical education indication
for them, and they're getting access to them through the internet.
I mean, this is a crazy, crazy problem.

Speaker 2 (01:58):
It's it's it's a system that has now bypassed all
the medical safeguards that we normally have in the society,
where if you wanted to get on a prescription drug,
you'd have to see a doctor, there would have to
be some reasonable indication for it, there would be someone
monitoring what you're doing. This is just literally going on
a website or going in the gray market and just

(02:18):
buying these things that are potentially dangerous medications, and people
are just using them as they see fit. These drugs
aren't designed aren't designed for you to lose five pounds.
They're designed to treat diabetes and for major weight loss
in people who are obese.

Speaker 1 (02:34):
Right, but let's first state make a statement like this.
I think this is among if not the most significant
medical breakthrough in the history of medicine. These drugs are amazing.
It's not the drugs that are the problem. It's the
rampant misuse of these drugs that are the problem, don't
you agree.

Speaker 2 (02:55):
Yeah, absolutely, I mean that's like most drugs, really, it's
you know, it's it's like someone taking a blood pressure
drug because they don't want to be one twenty over eighty,
they want to be one hundred over sixty. It's not
what the drug is designed to do, and it's never
been tested for these things. The way people are using it.

Speaker 1 (03:12):
Right, it's like we're going back in time to the
early two thousands when extreme thinness was a thing. Remember that,
it was like the thinner you are, the better it is,
when in fact, extreme thinness is actually a metabolic disorder
in and of itself.

Speaker 2 (03:31):
It's not healthy. In other words, people are taking this
to drug that's designed to improve your health and that
are amazing for improving health when they're used properly, and
using it in a state where they're already healthy, to
drive them to a point where they're no longer healthy.

Speaker 1 (03:46):
By the way, it's having the opposite effect. It's actually
making you look older, okay, it's actually giving you fatigue,
it's giving you electrolyte disorders, it's you're losing muscle and bone.
But actually, let's get a little bit not nerdy, but
a slightly doctory for a minute and talk about the

(04:08):
problem with the misuse of these drugs. Okay, because when
they're used properly and you maintain your muscle mass, they
cure metabolic disorders. Okay, they're fabulous for obesity, they're fabulous
for all sorts of indications. But when used in the
way that I'm seeing it with this anorexia ozempica, this
is the fundamental problem I'm seeing. You lose muscle mass,

(04:33):
the most important structural component of the body. And when
you lose muscle mass, what happens is your metabolic rate
goes down, right, And so as your metabolic rate goes down,
then your body goes into this conservation adaptation mode where
it's basically adapting to starvation, and that leads to a

(04:58):
whole bunch of problems in and of it.

Speaker 2 (05:00):
It leads to both short term and long term problems.
I mean short term. These people are walking around probably
dehydrated right at least acutely malnourished. They're not getting atticause.
It's very hard when you're using these medications this way
to take in adequate calories every day, because really, these

(05:22):
people are not meant to be These are not obese people.
They should not be living on say a thousand calories
or less per day. But it can be a challenge
to get in you know, depending on your man woman,
what size you are, I don't know, fifteen one hundred
to twenty two hundred calories, it can be difficult on
these medications.

Speaker 1 (05:39):
Practical examples of this their Doo Brooks Natter is the
model Yeah so yeah, yeah, so very attractive, Okay, but
actually talked a lot about the fact that she was
using and abusing these drugs the point where she was
throwing up, she was fatigued. She I think she passed out,

(06:00):
and furthermore, you know, it leads to thinning of the hair,
electrolyte disorders, you can't sleep, hormonal disruptions.

Speaker 2 (06:08):
By flaky skin, all kinds of things that, aside from
the health issues, are just unattractive.

Speaker 1 (06:14):
Yeah, menstruation problems. I mean, this is a disaster phenomenon
that no one is talking about, and I think it's
really important that we, for at least a moment or two,
highlight how to use these things properly, the red flags
that you need to look for when you're using these things,
and how to avoid this new newly recognized eating disorder

(06:40):
that's clearly going from endemic in you know, the major
metropolitan areas to becoming an epidemic throughout the country. Right, So,
what are the factors that you need to look for
when you're concerned about anorexia ozempica? I think number one
is you're on these drugs and you're losing weight too rapidly, right,

(07:00):
Number one, you shouldn't be losing one to two percent
of your body weight per week. It should be more
like a quarter to half percent a week.

Speaker 2 (07:08):
True at most, particularly if you're someone who's not obese
to begin with. First of all, if you're getting on
these medications to you know, lose ten pounds, you know, look,
people are gonna do it. It's just gonna happen because
it's it's like an easy cheat code for losing weight.

(07:28):
It takes away the cravings and you'll do it. But
if you're doing it at that point, you've got to
be really really careful. You don't have that much room
to play with, you know, if you're not If you're
one hundred pounds overweight, then you've got huge fat stores
that your body can start working off of. But for
the average person who's just trying to lose a few pounds,
you don't have that. And so if you get on

(07:51):
these medications, your body is immediately going to start getting
more of its calories because you're not taking in enough.
It doesn't have enough fat to do that. It's gonna
start breaking down muscle and healthy lean tissue immediately immediately.

Speaker 1 (08:06):
So the number two red flag for me is zero appetite.
I mean, I've gone out with couples that I know,
the women and maybe some of the men are taking
these drugs and they're eating literally nothing. The goal is
not to eat nothing, okay, And as I always say
to Heather, you know, it doesn't look good to be

(08:30):
that thin, I always say to her, And this is grotesque,
but I'm gonna say it anyway. No one wants to
fuck a skeleton, Okay. If you're doing this to look good,
all right, it's having the opposite effect. So zero appetite
is not the goal.

Speaker 2 (08:44):
No, it's well aside from it just not being the goal.
If you're not look, if you're going to be on
these drugs and you don't want it. First of all,
you don't want to get ridiculously lean. The goal is
not to have the body fat of a bodybuilder who's
about to enter competition. Bodybuilders don't do that. They lean

(09:06):
down right before the competition. They don't get down to
like single digit body fat levels and live at that
because it's unhealthy. It's not doable, and frankly, for everyday purposes,
particularly in women, it doesn't look good.

Speaker 1 (09:21):
I mean, I don't know if you watch the Oscar
Red Carpet, but I mean it. And I don't want
to body shame anyone. I think they're all very beautiful obviously,
and they're very talented, but I mean, you know, in
the middle of watching the Red Carpet, I thought to myself,
what is this the ozempics or is this the oscars?
You know what I mean? I mean, I just think
people are taking this too far, okay, And if the

(09:45):
other red flag is you're just not eating enough protein,
this is really all about muscle wasting and protein. And
what do you tell your patients how many grams poor
kilogram or body pound should they eat in protein?

Speaker 2 (10:00):
Well, if they're going to be on this at least
one and probably about one point five in reality. So
I would recommend to anyone who's taking this, first of all,
if you're going to be taking these, see your doctor
and get it prescribed properly and be monitored for this.

(10:21):
You need to have labs check periodically. You need to
be looked at. And a lot of these telem medicine
sites that do this, yeah, they're kind of getting around
because there's a doctor that you get on a zoom
call with and they make you fill out a questionnaire.
That's not really that's not really medicine. Let's not get
ourselves medicine to get on one of these medications, particularly

(10:43):
for questionable goals. You need to see someone. They need
to a physical exam on you. You need to get some
labs done, You need to make sure that this isn't
that first of all, you're in the right state of
health to start it, and someone needs to be monitoring
this as you go. And then you need to be
supplementing your protein and you need to be lifting weights.
You need to be doing strength training minimum of two

(11:05):
times a week to maintain or you are going to
lose muscle mass and you're going to get weaker, and
as that happens, your metabolic rade is going to drop.
So good luck getting off of these medications. Afterwards, when
you've been in a starvation mode for a long time,
you're going to start gaining weight very rapidly. So, now,
by the way, stock on these meds. That's exactly the point.

(11:26):
That is an a super important point. If your metabolic
rate goes down too quickly and you get off these drugs,
you're going to have such rapid gain regain that it's
just going to rebound horribly for you. So the act
opposite of what you want to maintain is what happens. Now,
let's talk about this whole thing with rediitruy tide. Okay. Yeah.

Speaker 1 (11:48):
The problem is is that whether we like it or not,
whether we suggest that people should be on medical supervision,
have the proper indications, whether BMI grader than thirty or
greater than twenty seven with a COMORBIDITI like hypertension, blah
blah blah, all those doctory things that you or I
would say. At the end of the day, we have
to acknowledge people are going to get these from compounding pharmacies. Okay,

(12:11):
they're just going to do it. So I think it's
better for us to acknowledge that they're going to get
them this way and at least give some advice that
if you are going to get on REHDTA, this is
how you should do it. The problem is, if you
haven't heard about Rihtta or Rehta truetide. It's one of
the most amazing phenomenons I've ever seen in medicine where

(12:32):
a drug that's not even FDA approved yet not even
been proven to be safe, is one of the most
powerful and popular drugs that people are using to induce
this medical starvation. It's so easy to get and all
you have to do is get near talk about Rehtta

(12:53):
near your phone, and the next time you scroll mindlessly
on your phone, it's going to show you no nothing
but Jim Brow's chiropractors and high school grads talking about
the medical indications for these drugs REDDA. But let's talk
about what REDDA is, because I think we have to
acknowledge people are just going to use this REDDA even

(13:14):
before Eli Lilly approves this drug. We don't want you to.

Speaker 2 (13:18):
Yeah, but what is if you're hitting on I think, well,
I think you're hitting on something really important here, aside
from just the health risks of being on these drugs
in a non prescribed, just experimental way, is the situation
we have now is going to break the pharmaceutical industry

(13:41):
in this country if it continues. And look, I'm no
fan of big pharma, but everyone and his brother is
making money off of REDDA true Tide now except Eli Lilly,
who can't make any money off of it, which is
the company that developed a drug. So if we start
doing this with every promising medication that comes out, where

(14:03):
immediately compound pharmacies are selling it and everyone is selling
it online. I think waiters are slipping it in my
food now at meals. You know, it's it's like it's
it's it's it's just ubiquitous. Right. It's like everyone but
the actual intellectual property owner of the medication is making
money off of it. There's no way Eli Lilly is
gonna sit still for this.

Speaker 1 (14:24):
Well, it's crazy because what's going to encourage them to
make the two billion dollar investment to get these things
it proved. But let's let's for those who don't know,
let's talk about quickly what Retitruetide is. Okay, so just
very very briefly, as you know, ozempic is GLP one.
That's ozempic and govi. Okay, that's the first proc. The
single agonist it's called manjarro and zep bound are GLP

(14:48):
one and GIP. Those are two hormones naturally found in
the body. And then the big breakthrough with retitrue tide
is it's a triple agonist. It's not only GLP one,
it's GIP and it's a glucagon rect agonist. Okay, So
ideally it fat burns. Ideally it preserves theoretically muscle mass.
We're hoping that it does all this safely. We don't

(15:10):
know because it's not FT approved, but it's so powerful
and I think it's going to be the first trillion
dollar drug. But I bet you there are more people
on illegal, unapproved, unsafe who knows where it came from
retitruetide than probably almost any other drug out there.

Speaker 2 (15:29):
Yeah, and that's probably true for most people taking the
golp ones as well. It's they're on really questionably sourced drugs.
And so because if you're not getting it from the manufacturer,
you're getting it from a compounding pharmacy that either makes
it here domestically, or more likely it's being made in China.

(15:51):
So aside from the fact that one, you're using this
in a way that it wasn't designed to be used,
that it hasn't been tested for it all these PEO
people creating their own dosing regimens. Okay, that's you're running
the experiment on yourself, basically. Yeah. But also, but aside
from the fact just the you're taking something a drug

(16:12):
that's not the design for the purpose you're using it for.
You're using it in doses that it's never been tested for.
You're getting on and off of it, which is probably
even worse for muscle loss over the long run. In
addition to that, you don't even know that you're getting
the actual drug, and if it is the actual drug,
you don't know what contaminants are in it. You are

(16:33):
literally running the experiment on yourself.

Speaker 1 (16:37):
Okay, So it's very clear we don't recommend you get
it from a compounding pharmacy because, by the way, it's
illegal for them to compound a drug that's not EFTY approved.
It's illegal, unauthorized, uncool, it's actually a criminal act. But
let's assume for a moment that somebody is going to
get rettritide on the let's assume someone may have Yeah, okay,

(17:01):
let's see that that's being done. Okay, lowest possible effective dose.
That's point number one. Absolutely start at the lowest dose
and retitrue tide because of the fat burning component, may
take a little bit longer. Then we'll go via a
zembic or zep bound or any other GLP one drugs

(17:22):
to actually kick in. So the goal is not zero appetite.
The goal is not for you to lose five pounds
per week. The goal is to diminish your appetite. These
are appetite suppressants with hopefully retitrue tide kicking in a
fat burning component. So keep the dose very low. If

(17:43):
it doesn't work for a week or two or three,
that's okay. Just don't raise the dose yet because we
don't know what you're injecting into yourself.

Speaker 2 (17:52):
Okay.

Speaker 1 (17:53):
By the way, you ever seen this FX show The Beauty.

Speaker 2 (17:58):
I don't think so.

Speaker 1 (17:59):
Oh, it's really good. By the way, Ashton Kutcher stars
in it, and it's about this shot that you can take. Okay,
Ryan Murphy's show, which turns you into like a supermodel, young,
amazing version of yourself. The problem is when a version
of it that got out of the lab was being used,
people would literally explode and spread their guts everywhere. And

(18:23):
I'm not saying reditruetide is the next the beauty shot.
But at the end of the day, if there's something
like an endotoxin, which is a viral sort of impregnated
bacteria or microorganism in it that takes a while for

(18:43):
it to manifest, we couldn't be injecting ourselves with something
that could lead to a very significant for example, neurologic
disease later like Kreutzfeld, Jacob Kreutzfeld, you know that one. Yeah,
the matt basically the human mad cow disease, human mad
cow disease. And you know, I'm not here to scare anybody.

(19:03):
And again I'm not saying anarexia ozempica is a psychiatric disorder,
but I mean we may be falling off a cliff
into this unknown abyss that we're setting ourselves up for.
That may be a giant problem. But having said that,
let's go back to how to use this redit true tide.

(19:24):
If you must, if you're going to okay.

Speaker 2 (19:27):
So we may be going off a giant, disastrous cliff.
But in case, you're gonna do it anyways, but we're
gonna get yeah, yeah, Well, look, I see one thing
needs to be stated here, Okay, and I can. I
totally understand the motivation to use these and I'm not
opposed at all to using it, but I think that

(19:49):
most people. Look, if you're gonna use it, you're gonna
do these things, do it with full awareness of the
risks that you're taking. And said, I have no problem
if we go to this sort of model for most
medications in the country. The problem is if you go
to this, you're acting as your own doctor, and so

(20:12):
at this point it's on you to educate yourself. Okay,
what am I going to get out of this? It's
getting my body fat percentage down to fifteen percent. Worth
being on a medication where we don't know what it's
going to do to us ten years from now. Because
that's true for semaglue tie, that's true for all of them.
The longest term studies on most of these medications in

(20:33):
big studies is maybe four years. That's not really long,
and those studies are mostly on diabetics, which is what
the medications were developed for so just know that. Yeah,
I see the value in looking ripped and handsome and pretty, right,
but there are a lot of unknowns in this.

Speaker 1 (20:55):
Yeah, I think it in terms of also more practical
things we can suggest. Decide on an endpoint. Okay, maybe not.
You know, your your high school, your your weight when
you were fifteen and you had that sudden growth spur
and all of a sudden you got skinny, just biologically
creat So yeah, by the way, I was totally a

(21:16):
chubby when I was on the tennis team in high school.

Speaker 2 (21:18):
They gave me the Turtle Award. I was very chubby.
Never heard this about you before.

Speaker 1 (21:22):
On a decide on what a reasonable end point is, Okay,
So if if you know you're twenty pounds overweight, and
that's a real twenty pounds, right, meaning you're not trying
to get down to your married weight, your bridal weight,
but some reasonable weight. When you hit that point, back off, okay,
back off, make sure you're eating the proper protein, do

(21:45):
your resistance training, and you know the moment Eli Lilly,
for example, is able to get this FT approved to
come out, maybe switch to the actual real pharmaceutical version
rather than this unknown one because you know, well I know,
I don't know if you know about I'm sure you do.
RFK Junior has decided to decategorize fourteen of the peptides

(22:09):
from category two, which means they're illegal, to category one,
which means compounding pharmacies can actually make them legally, right,
all right, that isn't that's not that hasn't been passed yet.
It's still legal to get the peptides, but everybody's doing
it anyway. It will never be legal to compound reda
true Tide ever, because it's not FDA approved, Okay, it

(22:32):
will never be legal to do that. So the end
of the day, these drugs like Reddit True Tide are
being shifted towards from the grayish market to the black market,
where you know, it's the guy behind the gym with
the you know, the lunch bag and the trend bologne
or whatever and the you know, the test and the anavar,

(22:53):
you know, that kind of scummy kind of sourcing of it,
where they're a lot more dangerous and a lot more suspect.
I mean, I'm just I'm really worried that this is
going to blow up in our face. And listen, no
one wants to take retitruetide more than me. Okay, I
really like the idea of fat burning and controlling my

(23:16):
appetite because I've always been victimized by my appetite. You
know me, Rob, I can literally eat till I'm full
and then still shove more food in. You know, I
find a place in my satiety center where I'm shoving
it in on just adjacent to nausea I can go.
I can't tell you how many times I've woke woken

(23:37):
up at three o'clock in the morning and you know,
had to go and throw up because I've just eaten
too much. I'm I can relate to those people who
have no control over their app I mean, I'm the
perfect person for a GLP one because for me, appetite
suppression would be extraordinarily helpful. Right, But this retitruetide, I mean,

(24:00):
I don't know at what cost? You know, what are
we trading for this?

Speaker 2 (24:12):
First of all, it's good that you wake up before
throwing up, At least from Heather's standpoint, probably that's got
to be a huge plus for her. Look the goal
in terms of you, it's you're looking for a little
bit of appetite suppression. You're not looking to kill all
of your appetite, right, So if people are taking this,
the goal is to just get to the point where

(24:33):
you have a sense of control at meals, so you
can eat a sensible portion and not overeat. The goal
isn't that you look at a plate of food just gough,
I don't want any of it. And that's unfortunately the
way a lot of people are doing this. And by
the way, you know, I don't see a compelling reason
at the moment to use red atruetide because you can

(24:57):
get you know, you can get munjaro, you can get ozampic,
all of these are available through prescription. You know you're
getting the actual, real, pure product. And if I believe,
I just heard that Costco is now doing a month's
supply for about five hundred dollars, and so the price
is getting into a place that's reasonable on these things.

(25:18):
Why take something that isn't even FDA approved yet, that
you can only get through backdoor channels? Why do Yeah,
by the way, that we have better medication, but what
we have is more than good enough at the moment.

Speaker 1 (25:31):
By the way, that's a really important point, because you
can go to Lily dot com and get into their
telehealth thing and not actually even have to go in
necessarily to see a doctor answer some questions, and then
get a prescription from them and go and get the
real thing. Right. Yeah, So you've just.

Speaker 2 (25:51):
Eliminated a whole category of risk just by doing that.
One that you're getting the real drug, and two that
it's not filled with kind of dangerous and pure these
heavy metals, all kinds of things that you don't know
what you're injecting because you don't know who made this
or how much they cared, or or or or exactly
what you're getting. You just don't want to take gray

(26:11):
market drugs, you know what.

Speaker 1 (26:12):
The other problem is the rub there are I think
no less than twelve to fifteen other weight loss drugs
in the pipeline that will come out, from pills to injectables,
to things that cause you know, your muscles to hypertrophy,
like a steroid would added on to red a true time.
I mean, wonderful things are coming down the pipe, but

(26:36):
what happens when those things are compounded before they come
out and it really gets out of control? Listen, you
do not want to be a guinea pig for these
unknown drugs that f with your metabolic rate, that f
with because the one thing that occurs, particularly in those
of us who are over fifty, is there comes a

(26:58):
point physiological where this frailty gene kind of kicks in.
And you've seen people like this who are like sixty
sixty three who don't work out, it, don't eat protein,
and all of a sudden, they just look old. And
that that's a condition of frailty that is kind of
semi irreversible. Once frailty kicks in, it's very difficult to

(27:24):
go back. But you can either delay avoid it all together,
or certainly delay it by years and years by resistance training,
by protein, by minimizing lean muscle mass. Oh, and the
other thing when you lose muscle, minimizing loss of lean
muscle mass. When you lose muscle mass, okay, your bones thin.

Speaker 2 (27:44):
When we were in general surgery, Okay, an older person
who fell and broke their hip, and that begins basically
a death spiral because they're already frail, right, because that's
why they have the brittle osteophrotic bones to begin with.
And then they don't have the reserve, they don't have
the muscle mats. They don't have the nutrition, they don't

(28:05):
have the health reserve to recover from this, and then
they get pneumonia, and then they go downhill from there,
and these people end up dying from these sort of things.
So the problem with using these medical if you're using
these medications as part of everything else that you're doing
for your health, good diet, good sleep, exercise that includes

(28:26):
strength training, that includes zone two cardio, that includes high
intensity cardio, all the things you should be doing, then yeah,
maybe as a supplement if you're using these meds to
bypass doing all of that. One you're not gonna look
good because you're just not gonna be healthy, you're gonna
be mountain nourished, and two you're setting yourself up for

(28:47):
premature death.

Speaker 1 (28:48):
In my book, well, the thing I'm worried about is
it's gonna take that sentinel event. Some celebrity, some young
influencer is gonna take this too far with these GLP
one drugs and literally overdose to the point where they
haven't eaten, they're completely malnourished, they have an electrolyte abnormality,

(29:10):
and then a cardiac event, and then then we're all
going to go, Okay, that's gonna be the wake up call.
What we're hoping with this kind of message is that
you don't we don't have to wait for that sentinel event,
for that wake up call of some influencer celebrity.

Speaker 2 (29:27):
I think, if I remember correctly, Brooke Nader had an
episode where her family found her passed out in like
a tub full of water because she was either so malnourished,
dehydrate and electrolytes out of abnormal. It's something along those lines.
I don't know that they said what the reason was,
but she ascribed it to being on these drugs and

(29:49):
using them incorrectly.

Speaker 1 (29:52):
You know, it's funny because we're plastic surgeons and health
and wellness experts and so on, but it reminds me
of you know, when breast dogm first happened, when vpls
first came out, when lepelsoaktion first happened. Oh this is great,
and all of a sudden, you know, because of some
influencer or some big celebrity pushing the envelopes. Now it's

(30:12):
eight hundred ccs in each breast, and then it went
to fifteen hundred CC's and then injecting four leaders in
each butty cheek. You know this is going to go
down that path of excess. There's no question about it.
The question is are you going to be the person
who does that or are you going to be smart
and do it under medical supervision? Eat your protein, do

(30:35):
your resistance training, check your labs. By the way, I
think everybody, everyone before they go on one of these drugs,
should get what a metabolic blood panel completely profile.

Speaker 2 (30:45):
Yeah. Yeah, and by the way, you can just there's
plenty of places you can just go and get it
on yourself. Now, it's not expensive, it's easy to do.
And look, it's the kind of thing that if you're
not going to your doctor every year and getting this done,
you should be and or get it yourself. Know where
you stand on these things, This isn't hard to do.

Speaker 1 (31:05):
One thing I noticed is, you know, every time before
these drugs came out, I used to look at Leonardo DiCaprio, right,
one of the great actors of our era, and you know,
he's single and dates a lot of young models, and
you know, because he can and so on. But I
look at this guy on vacation in the yachts, and
he's a guy hell is he like fifty years old now.

Speaker 2 (31:29):
Something around there? All right, But every.

Speaker 1 (31:31):
Time I see him on the yacht. You know, we're
all allowed to gain some weight and you know, go
off our diet between whatever he's doing, movies.

Speaker 2 (31:39):
And so on.

Speaker 1 (31:39):
But Leonardo DiCaprio has looked at various times pretty out
of shape, pretty chunky, pretty, you know, like I'm on
the carb straight diet. Have you noticed that about him?
And I've always wondered Dad bod plus at least dad blood,
Leonardo dad bud.

Speaker 2 (31:58):
Like sub average dad. And look, right, I don't want
to crap on Leonardo DiCaprio. I wish I looked like
Leonardo DiCaprio, even now, even at his worst, Dad bought.
Leonardo DiCaprio has always been and still is, very good looking.
But I think you make a really good point here
is you can look at Leonardo DiCaprio's face now at

(32:19):
fifty three or whatever he is, and you can see
the hard living that he has done, the partying, whatever
substances he's done, the maybe one too many nineteen year
old models, maybe one too many nights up partying. All
it takes its toll, Harry. It takes it's toll.

Speaker 1 (32:40):
It does. But at the Oscars, though Leonardo DiCaprio looked
decisively thinner, he looked very glp one to me, Now
he looked better, didn't you think?

Speaker 2 (32:51):
I think he did. I think he did. I think
he definitely looked better than how he looked a few
years ago, when I think he was at his doe.
But you can see the consequences of the way he's
lived in his face and in his body now because
he looked good, he looked better than he did. He

(33:12):
still looks great. Like I said, I would swap his
life for mine, and the way he looks right now
for the way I look. But on the other hand,
he doesn't look anywhere near as good as Leonardo DiCaprio
could look at fifty three if he had maintained his
health throughout, which he obviously has not. He doesn't look healthy.

Speaker 1 (33:31):
Now, right, That's the problem. You can abuse yourself at
twenty three and look fine at twenty five. You can
abuse yourself to a certain degree at thirty three and
still look okay at thirty five. Right, you abuse yourself
at fifty two. I think cosmetically, esthetically you might not
be able to go back to the way you used

(33:55):
to look. And I think he's danger close to if
he doesn't get his act together right, stay on the
excise regimen, you know, do the GLP one drugs. If
he has a medical and I mean he's look, he's
had a medical indication for GLP one drugs. I'm sure
as BMI was greater than twenty seven at some point
was out of question. But I think Leonardo DiCaprio, you know,

(34:17):
I think he's the most brilliant actor, but he's a
good example of he's on the rapid path to maybe
a Jack Nicholson type irreversibility if he doesn't get his
act together, don't you think.

Speaker 2 (34:29):
Well, I think you can already see. And again, I
you know, there's a part of me that doesn't like
doing this because it's a little unfair to celebrities because look,
we all get just crappier as we get older. True,
but the problem for them is that, you know, there
are a million pictures of me out there when I

(34:51):
was twenty five, you know, looking way better than I
do right now that people go, oh yeah, because I
see this clipbait all the time. It's like, you wouldn't
believe how ugly Bridget Bardow is now. I'm like she's ninety. Yeah,
of course she doesn't look like she looked in nineteen
sixty five. But the problem for celebrities is being in
that level of the spotlight all the time. Everyone is

(35:15):
constantly looking at you from every angle and just endlessly
critiquing you. But you know, I think for you know,
you make the point that you can't at such a
certain age, you can't go back in others, if you
do the damage, it's probably irreversible, and I think it is.
But I think at any point, if you don't take

(35:35):
care of yourself, or if you're thirty and you don't
take care of yourself for a ten year span, you're
paying the price regardless. Can you reverse a lot of
it at forty Yeah? But are you ever going to
look as good in the future as you would have
looked had you just maintained everything through your whole life,
kept a stable weight, maintain good health, worked out.

Speaker 1 (35:57):
Nope, you're not well going to think two two really
good examples. George Clooney. This is a guy who takes
care of himself. He may drink a bit, but he
takes care of himself. He clearly keeps his weight locked in.
He's very active, you know, he loves basketball. He's very fit.
And Harrison Ford. I think Harrison Ford has done an

(36:19):
amazing job at self preservation, longevity preservation, and maintenance. These
are people who have gotten naturally older. But you know,
you can tell that the years of over use of
various things. Rather than use the word abuse, I'm going
to say over enthusiastic use of those things you know

(36:41):
when you're younger hasn't hasn't necessarily taken its toll. And
you know, and obviously Tom Cruise. Tom Cruise has never
let himself go.

Speaker 2 (36:50):
Brad Pitt, who we talked about, who we talked about
on the last episode, same category.

Speaker 1 (36:54):
Yeah, well, Brad Pitt.

Speaker 2 (36:55):
I've never seen Brad Pitt looking unhealthy.

Speaker 1 (36:58):
No, And I think he did talk about the fact
that he had some drinking issues and that he's been
sober for just forever. Now. I mean, I'm not a
fan of being completely sober, all right. I enjoy my
intermittent cocktail, all right. And whether that has taken a

(37:19):
toll on the way I look or not, maybe, but
I'm okay with that just as long as it hasn't
taken a toll on me physically, which I'm so surveilled
and so monitored. I know exactly how much plaque is
in my carotid arteries. You know, I know where I'm
at physiologically, So I know I'm okay. But you know,
maybe not everybody monitors themselves as closely as I do.

(37:42):
Do you do you do that kind of monitoring of yourself?

Speaker 2 (37:45):
Your level of obsessed with monitoring? Now? No, probably you
basically where you have a home, MRI. Now I don't
have that. But look, you look obviously older than we
met eventually the same so lean You're probably leaner and
more muscular now than you were when I knew you

(38:07):
in your twenties. So you're you know, your false modesty aside,
you look, you look great, but you know you take
Let's go back to Leonardo DiCaprio for second, okay, because
I think this is instructive on the what it does
to you when you don't maintain this. Okay. So I
looked really closely at photos of him at the last oscars,

(38:29):
and if you look at him compared to how he
looked when he was younger, when he was younger, he
had sort of that sort of a heart shape to
his face, more fullness in his upper cheeks, less fullness
and his lower cheeks and everything kind of tapered in.
It was almost like a bit of a feminine face. Right.
If you look at him now, he's got some fairly

(38:50):
heavy jowling for a man of his size, and he
has no fullness in his upper cheeks, which means that
all the internal soft tissue of the cheeks has descended
from the upper cheeks down into the lower cheeks. And
it's it's fine in a man to some extent, it's
you know, it looks rugged. He's starting to look like

(39:11):
he's slowly merging with Tom Selleck so especially with the mustache.
But that's a consequence of the weight changes. Yeah, gain
a bunch of weight, All of the ligaments in your face,
all of that tissue stretches out. When you lose the
weight again, the fact goes away, some of that fullness
goes away, and everything drops. So it just brings us

(39:32):
full circle to the you gotta stay healthy. You got
to maintain a stable weight, yeah, or you're gonna pay
the Even someone as good looking as him, it's going
to pay the price, one way or another.

Speaker 1 (39:44):
So at the end of the day, although we just
had a whole discussion about the dangers of misuse over
use of the GLP ones, and someone like him, under
proper medical supervision, under proper surveillance, GLP one might be
life extending, life saving, preserving his looks completely and totally

(40:07):
and actually.

Speaker 2 (40:08):
A very good idea when you agree, Yeah, look, I
think it may or may not be a good idea
for a lot of people, you know, in that age range,
our age range. You know, there are definitely there's definitely
evidence that these have cardiovascular benefits. It probably has a
lot of metabolic benefits. The problem is is that, you know,

(40:32):
a little bit, at least scientifically, the jury is still out.
There aren't long term studies and there's really very little
in the way of studies on their youth, their use
on healthy, reasonably fit people, which is a lot of
the people who are using this right now, so that's
completely unstudied. So, yeah, there's no question that they have

(40:54):
longevity benefits in people who are morbidly obese or somewhat
obs or you know, bm I over twenty seven. Yeah,
because those people have a lot more health risks and
you start losing that weight and improving metabolically, Yeah, that's
gonna have benefits. But what if you have a BMI
of twenty one or twenty two and you're starting out
and you're completely healthy, and you're thirty years old, and

(41:17):
you're maybe signing up to do this for the next
forty years of your life.

Speaker 1 (41:22):
Well, you're in.

Speaker 2 (41:23):
You're in. You're in the study group when you may
want to be in the placebo group for this study. Right,
that's true, because now, let's.

Speaker 1 (41:30):
Be honest, certainly in Hollywood, being on a GLP one,
being on REDDA, being on Monjaro at a BMI of
twenty three, which is probably a female's five to seven
ways what one ten is probably a BMI of twenty three.
I mean, this is a person who shouldn't lose any weight.

(41:58):
Oh and that reminds me. So you ever heard of
this the Mormon Wife cast member named Layla.

Speaker 2 (42:08):
Yeah, I know, I know a little bit of the story.

Speaker 1 (42:10):
Yeah, super Thin went on one of these GLP one drugs.
I mean that that really is enabling not only body dysmorphia,
that's enabling an eating disorder. That's really you know, yeah,
out there.

Speaker 2 (42:29):
I think if I remember correctly, She said she struggled
with eating disorders her whole life. Right, and the last
thing we need is people using these drugs to enable
their known eating disorders. Right. You know, if you've got
an eating disorder and you struggle with body dysmorphia and
you're already very lean and you're thinking about you know,

(42:54):
if you're in a BMI of twenty and you want
to get on this to get to a BMI of
eighteen or something like that, it's time to seek help.

Speaker 1 (43:04):
Yeah. I mean, if you're looking to get to your
birth weight, that's not a great goal. Okay, that's a problem.

Speaker 2 (43:11):
These people are using. Some people are using this to
basically treat they're eating disorder, and exactly the way you
don't want to treat an eating disorder, which is by
making it more effective.

Speaker 1 (43:23):
Yeah, I mean, it's giving a gambling addict, you know,
access to a slot machine. For those in the audience
that don't know, your BMI is your body mass index
and it's a relationship between your height and your weight
and gives you a good proxy measure of how much
body fat you have and how much visceral fat and

(43:44):
whether you should lose weight or not, and anything over
thirty is considered class one obesity, over thirty five is
Class two OBC, and over forty is Class three, the
most severe level of obesity, and twenty five to thirty
is overweight, and twenty to twenty five is sort of
underweight or probably okay. And you know, you don't want

(44:07):
to overfocus on BMI too much, but because it's not
perfectly accurate, I mean, ideally someone would get it before
they go on these drugs because you really want to
focus on the muscle mask compartment. You get a DEXA scan,
you get baseline blood panels, you go to a doctor.

Speaker 2 (44:26):
You have an EKG.

Speaker 1 (44:27):
But we know that very few people in these drugs
actually do that, right.

Speaker 2 (44:33):
Let's see, I think the majority of people doing this
the compounding route are at best getting it from some
telehealth site where they've seen some on screen doctor for
ten minutes, which is not I mean, it passes the test,
but it's not really what you want to do, and

(44:54):
that's probably at best. At worst, they're getting it, like
you said, from the behind the gym, yeah, you know,
or from whatever their local seven eleven or dry clean
or whatever. Yeah, because everyone is selling reditrue Tide except
you light lily. Yeah.

Speaker 1 (45:11):
I mean, we're gonna wrap this up, but I just
want to say that, you know, with a gigantic grain
of salt, when you listen to these Jim Brows and
chiropractors and personal trainers on YouTube and social media, when
they give these advice about these peptides, they are giving,
make no bones about it, they are giving straight up

(45:33):
medical advice with zero medical training. And it in my mind,
you know, medical doctor bums me out. But it really
amounts to the abating and abedding the lightest light unlicensed
practice of medicine. Blah blah blah. But just just be
very careful where you.

Speaker 2 (45:51):
Get your advice from. Here's what I would tell you
if you're thinking of going that route. Okay, you, as
the user of one of these drugs, knows already as
much or more than the person who's selling it to you.
In these circumstances, they don't know anything. You don't know.
They're getting their information just like you, off of TikTok

(46:13):
or Instagram. They're not reading the medical studies in the Lancet,
so you know, or you can know easily as much
or more about them. So if you're going to go
this route. And I think we agree, we don't really
recommend doing this. We recommend doing this through a doctor.
We don't. I think we could sum up by saying

(46:33):
that we're not saying don't do this, we're saying this,
do this with some caution, and do it carefully, and
do it as part of a sensible program. These drugs
do have a role, and they're frankly amazing, but do
it in a way that you're protecting yourself, where you're
taking reasonable precautions. And if you're going to do these drugs,

(46:54):
you have the entire knowledge of the entire medical world
in your pocket, on your iPhone, Get on chat GPT,
get on Google, read some stuff about it, know what
you're getting into, and then if you want to do
it and make an educated decision, then go to your
doctor and do it appropriately so you know that you're
getting the pure drug and you're being monitored, and you're

(47:16):
doing this safely, and it's not only improving your looks,
it's making you healthier instead of sick.

Speaker 1 (47:21):
Okay, I think that's perfect advice. And I think Chat
GBT is as bad as doctor Google used to be.
Chat TBT is a very good medical clinician very good.

Speaker 2 (47:32):
So I'm consistently blown away by it that I can
basically scan like a page of lab results and go, hey,
what do you think of this? And it nails it.

Speaker 1 (47:41):
Yeah, it's incredible. Well, I think that was fun, really important,
and I hope people appreciate that. We're not saying it's
anarexia nervosa. It's not a psychiatric disorder. It's just a
misuse of a very important, historic drug that really needs
to be looked at very carefully and done with great caution.

Speaker 2 (48:04):
Right. It's like a lot of things in our industry.
It's you know, most of plastic surgery is great. It
becomes a problem when people take it to extremes. Yeah,
you know, when you go too far. When you said
when you put in fifteen hundred CC implants, it's the
same thing. It's taking something that is a really powerful
tool for beauty and self esteem and turning it into

(48:27):
something potentially dangerous. So don't do it. Just use it sensibly.

Speaker 1 (48:32):
Okay, Well, until next time. I hope you all enjoyed that,
and we'll see you, hopefully very soon.
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