The Male Room with Dr. Jesse Mills

Writer and Peyronie’s disease advocate Don Cummings joins Dr. Mills to share the deeply personal—and often surprisingly funny—story behind his memoir, Bent But Not Broken. Don recounts the fear, guilt and depression he experienced after developing Peyronie’s at age 48, as well as the long treatment journey that ultimately restored his sexual function. He also explains how support from his husband, family, fr...

Dr. Mills is joined by University of Washington urologist Dr. Marah Hehemann to explain how Xiaflex injections can treat the curvature caused by Peyronie’s disease. They discuss who makes a good candidate, what the six-month treatment process involves, and the realistic benefits, risks and side effects patients should expect. The conversation also explores penile traction, surgical options when injections are not enough, and ...

Dr. Mills dives deep into the surgical side of Peyronie's disease with Professor Matt Ziegelman from the Mayo Clinic, one of the most renowned Peyronie's surgeons in the country. Building on previous episodes covering the disease's natural history and treatments, this conversation explores the intricate surgical options — including the highly complex plaque excision and graft procedure, which requires essentially disassemblin...

In the first installment of our multi-part series on Peyronie's disease, Dr. Mills explains what causes the condition, how it can change the shape, length and function of the penis, and why it may be far more common than most men realize. He also traces its unusual medical history, separates Peyronie's from congenital curvature and dispels the damaging idea that patients somehow caused it themselves. From medications and traction d...

Clinical psychologist and USC professor Dr. Darby Saxbe joins The Male Room to unpack the science behind fatherhood, from the ways caregiving reshapes the brain to how testosterone, sleep loss, stress and postpartum mood changes can affect new dads. Drawing from her new book Dad Brain, Saxbe explains why great fathers are made through practice, presence and repetition and not just biology. The conversation also explores dad bods, m...

What happens when a man finishes too quickly — or struggles to finish at all? Dr. Jesse Mills explains why issues like premature ejaculation and delayed orgasm are more common than many men realize, and walks through the treatments that may help. He and Jordan also discuss unrealistic expectations shaped by porn, the internet phenomenon known as “death grip syndrome,” and why honest communication with a partner is...

Dr. Mills and Jordan tackle one of the most common — and least openly discussed — insecurities among men: penis size. Inspired in part by a story from recent guest Jordan Ritter Conn's new book American Men, the pair explore the surprising history of cultural attitudes toward penis size, how pornography and unrealistic expectations shape men's self-image, and why most men dr...

Dr. Mills speaks with writer Brad Snyder about the lasting emotional impact of childhood medical trauma, body shame, and the complicated relationship many men have with vulnerability. Drawing from a deeply personal HuffPost essay about his experience with an undescended testicle and humiliating pediatric exams, Snyder opens up about fear, secrecy, masculinity, and the long road toward self-acceptance. The conversation explores how ...

Dr. Mills sits down with journalist and author Jordan Ritter Conn to explore the emotional lives, hidden struggles, and evolving identities of modern American men. Drawing from his deeply reported new book American Men, Conn shares the stories of four vastly different men — from a closeted fighter and a haunted Army veteran to a trans man navigating life in the Rust Belt — and ex...

In this episode of The Male Room, Dr. Mills sits down with Admiral Dr. Brian Christine — Assistant Secretary for Health at the U.S. Department of Health and Human Services — for a sweeping conversation about the state of men’s health in America. From testosterone therapy and erectile dysfunction to depression, chronic disease, diet, and the alarming ways men avoid the healthcare s...

In this episode, Dr. Mills details the Five Ps of the Pen-ocalypse — a mix of real medical emergencies and under-discussed conditions that can derail even the healthiest sex life. From the urgent dangers of priapism and penile fracture to the lesser-known but equally important issues like phimosis, paraphimosis, and Peyronie’s disease, he breaks ...

Dr. Mills sits down with internationally acclaimed DJ, licensed therapist, and host of the iHeart podcast Music Is Therapy, DJ Hesta Prynn, to explore the surprising science behind music, mindset, and emotional health. From learning vinyl from Questlove to developing her “music connection therapy,” she b...

Dr. Mills sits down with cognitive neuroscientist, musician, and bestselling author Daniel Levitin for a wide-ranging conversation on the brain, music, and what it really means to age well. From the science of dopamine and why music can literally rewire the brain to the difference between lifespan and “healthspan,” Dr. Levitin breaks down complex ideas with the same clarity that made 'This Is Your Brain on Music' a mode...

Every guy wants to keep his hair—but not at the expense of everything else. Dr. Mills unpacks finasteride, its benefits, and the rare but real side effects that have fueled online panic around post-finasteride syndrome. Along the way: hormone deep-dives, myth-busting, and why “one-size-fits-all” medicine doesn’t work. It’s the truth about hair loss drugs—without the fear-mongering

See omnystudio.c...

Dr. Mills sits down with longtime collaborator Dr. Stanley Frencher Jr. for a wide-ranging conversation on healthcare disparities, entrepreneurship, and building systems that actually reach underserved communities. From his upbringing in a family of physicians to leading innovative care models in South Los Angeles, Frencher shares how his work with HubMD is ...

In Part 2 of our vasectomy series, Dr. Jesse Mills and Dr. Jay Sandlow dive into what happens when “permanent” birth control isn’t so permanent—breaking down the science, success factors, and surprising complexities of vasectomy reversals. From the difference between surgical techniques to the real-world variables that impact fertility—including partner age, prior history, and timing—they walk th...

March is vasectomy season (really) and to honor the occasion, Dr. Mills is joined by leading urologist Dr. Jay Sandlow—one of the architects behind modern vasectomy guidelines—for a candid, myth-busting conversation about one of the most common (and misunderstood) procedures in men’s health. Together, they break down who should consider a vasectomy, what actually happens during the procedure, and why it remains fa...

Dr. Mills walks listeners through what life after prostate cancer surgery can really look like, with a candid focus on sexual recovery, continence, and quality of life. He explains how “prehab” — including medication, pelvic floor exercises, nutrition, and follow-up care — can help men improve their odds of regaining function after treatment. Along the way, Dr. Mills and Jord...

Rock and Roll Hall of Famer Tim Commerford joins The Male Room to speak candidly about his prostate cancer journey — from the shock of diagnosis and the emotional aftermath of surgery to the hard-won strength he’s built on the other side. The Rage Against the Machine bassist opens up about masculinity, recovery, ...