Episode Transcript
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Speaker 1 (00:04):
Welcome to Wellness sun Mass. I'm doctor Nicole's halfire and
today we're going to talk about peptides, mainly because everyone
keeps asking me about them and I don't really know
much about them, So decided to do a little research
and spread some knowledge because if you haven't noticed, peptides
are becoming quite popular. There's a quiet revolution happening in
medicine right now, and it's not coming from big pharma.
(00:26):
It's coming from these peptide clinics and telehealth startups and
wellness and longevity communities. So people are using peptides for longevity,
muscle repair, fat loss, brain health. So the problem is
some people are just taking a whole bunch of random peptides, three, four,
even five at a time, with really no data whatsoever
(00:49):
that they're beneficial when used together and if there is
or is not any harm. So let's go just a
little bit deeper. Which peptides are being used, what do
they call aim to do, what data exists, and what
should make us pause before trying some of these peptides.
So let's start out with what peptides are. Peptides are
(01:11):
short chains of amino acids that act like little biologic
messengers in our body. They bind receptors and then they
trigger specific physiologic responses in our body. They increase growth, hormone,
stimulate collagen, reduce inflammation, improve mitochondrial function, and alter appetite signaling.
(01:31):
So think of them as like targeted biologic nudges. Instead
of like taking a medication to treat a disease, this
is taking something to help promote natural occurrences in the body.
That's why they're attractive. Most peptide use falls into really
three categories. You know, Number one the longevity slash anti
(01:53):
aging peptides. Number two, the one for you see athletes
talking about muscle repair and injury recovery peptides after an
injury during a game or a practice or whatever it is.
And then the last one being metabolic or the ones
that help you lose weight and maintain your blood sugar.
(02:14):
So let's talk about them. I bet you didn't realize this,
but you already know a little bit about peptides because
some peptides we've been talking about for over a century,
like insulin. Insulin is a peptide. A lot of people
think of it as a hormone, but it is a peptide,
and it helps regulate your blood sugar. What's another peptide
that you've heard a lot about recently, GLP one medications
(02:37):
like the ozempic, the wagovi and all of that, that's
also a peptide. At this point, there is very strong
robust data on those demonstrating benefits but also risk to
taking those medications. What I want to focus on today
are some of the lesser talked about peptides, the majority
which are not approved by the FDA and that are
(02:59):
kind of making their way onto social media platforms and
with influencers talking a lot about them. So these are
the ones that are dominating these conversations. The epitalon this
peptide is marketed as a telomerase activator, and that is
it essentially that it lengthens telomeres, and then telomeres are
(03:21):
essentially the protective caps on DNA that are associated with aging.
So if you are protecting those caps, then the theory
is that you are stopping aging or slowing it down. Now,
in animal studies, when they were given this peptide, it
(03:41):
did increase the lifespan in rodents, and it improved their
immune function and it reduced oxidative stress. Those are all
good things. And a very very small but human study
out of Russia showed that the use of this peptide
improves sleep and reduce mortality in elderly people, and they
(04:03):
suggested it may have caused some telomere stabilization, you know,
those protective caps on the DNA. But it was not
conclusive whatsoever, and it was very small study, not randomized.
This is not FDA proved. There's no long term safety data.
There's really no long term benefit data either, but it's
still being widely used in longevity clinics based off of
(04:25):
a theory. Now, the next one I want to talk
about is mots C. Mots C, Now this one is interesting.
MOTZ is a mitochondrial derived peptide, meaning it targets cellular energy. Now,
the claims with this one is it improves metabolic flexibility,
enhances insulin sensitivity, so your own insulin your body's producing
(04:50):
it makes your body more sensitive to it. It also
improves exercise performance, and it can slow aging pathways and
this is demonstrate in mouse data. And in the mouse
data it showed improved endurance, reduced obesity, improves insulin sensitivity,
and it increased lifespan markers, so that's interesting. And a
(05:14):
small human study showed improved exercise capacity and glucose metabolism,
but again very very small sample sizes. But this is
also one of the most commonly used longevity peptides right now,
another one fimocin alpha one. This is used in many
parts of the world actually for immune modulation, for viral infection,
(05:36):
cancer adjunct therapy. Longevity clinics are using it for immune resilience,
inflammation reduction, and recovery. Are some human data for this
peptide that shows improved immune cell function, reduced infection rates
in hy risk populations, and possible benefit in sepsis and
cancer adjunct therapy. Now for me, so wh who works
(05:56):
in cancer care, this has me very excited because we
can't just depend on antibiotics anti virals alone. We want
to make sure that we're doing something to boost the
natural immune system, and there's some data showing that this
peptide might actually do it. It actually has more clinical
credibility than many of the others. Does it still need
(06:19):
more human data, Yeah, of course it does. So if
you have someone who is sick or is at risk
for infections, yeah, absolutely, why not consider this. I would
love to see more human data, and I certainly would
like it to get FDA approved, because that's how you
get even more safety checks when something is FDA approved.
It's not there yet, but for me, this one definitely
(06:39):
holds some promise. And it's used in over thirty five countries,
specifically in patients who have hepatitis infection to help boost
the immune system. So I don't know, I like that one.
Thamusin alpha as sounds promising to me. Now, what about
muscle repair and injury peptides? You know myself, I've had
many many orthans copedic surgeries, and as we age, a
(07:02):
lot of people are starting to suffer from degenerative changes.
We tend to get a little bit more injured as
we try to play sports as we get older. So
I have a lot of friends who you know, asked
me about this a good amount. So these are the
most common ones that are used, like in athletes BPC one, five, seven,
And this might be the most talked about peptide right now,
(07:25):
because again you're starting to hear about it from the athletes.
It's derived from a gastrik, you know, coming from the
stomach a protein that comes from the stomach. Now, the
claims are it can help promote ten healing, ligament repair,
muscle recovery, anti inflammatory effects, and also gut repair. That's
(07:45):
an interesting one. Studies have shown that it does accelerate healing,
improve ligament strength, reduce muscle damage, and improved blood vessel
growth in areas of injury. Now, but here's the key.
There's almost no robust human trials on this, really only
based on animal studies and case reports and just anecdotes
(08:10):
from athletes. Yet it's widely being injected for rotator cuff injuries,
acl recovery. I've had both of those pennis elbow achilles
tendon injuries. So does it work? I don't know. Maybe
I'd love to see a study that showed just injecting
peptide randomized control. Some people can't really randomize it. But
(08:31):
some people will go and have surgery, and some people
will just have the peptides and then we see, you know,
if they have the same amount of rehab afterwards, we see,
you know, based on imaging and just you know, function,
how well it does. Or maybe the peptides are used
in conjunction with surgery. Do you have better outcomes if
you're also injecting peptides after surgery to help with that repair.
(08:55):
I don't know these We don't really have the answers
to these. It sounds if you have animal studies showing
that it can help with injury repair, then that seems
like a great place to start. But let's not stop there.
Let's now move on to the human trials to show
that we're actually having a benefit here and we're not
doing something that in ten twenty years is going to
(09:15):
have a negative effect on that joint. We don't really know,
and this is a very expensive industry. If something doesn't
really work, we don't want people spending their money on it.
TB five hundred it's another one. It's often stacked with
the one we just talked about, the BPC one five seven.
People are sending to do it together because it's also
(09:36):
supposed to stimulate tissue repair and reduce inflammation, heavily used
in athletes, bodybuilders, orthopedic recovery. Big concern with these ones though,
mind you, very limited studies. But of the limited study
the cell growth stimulation, it actually is a concern that
(09:57):
there's a theoretical cancer risk. So we have no knowledge
of the long term effects here. Obviously, the more cells
that are created, the higher the cellular turnover. That's when
rogue cells can happen, and that's when cancer can form.
So yeah, we want to stimulate new cell growth when
(10:18):
we are healing and in recovery, but you want to
be careful. You don't want to overstimulate cell growth because
that can lead to cancer. I wish we had a
study showing whether or not these peptides that everyone's injecting
actually done it. Now IGF one l R III, this
one's even more aggressive. The mechanism is it stimulates insulin
(10:39):
like growth factor, which promotes muscle hypertrophy or swelling or
making muscles bigger, and it increases other cell activations. People
use it for muscle gain, recovery from injury, and increase
their strength. Big concerns with this one is it can
cause hypoglycemia because it can stimulate insulin, so it can
(11:01):
drop your blood sugar. It can also lead to organ overgrowth,
so there's actually a congenital condition where you have insulin
like growth factor, you have too much of it, and
organomegaly or too large of organs is one of the
side effects, and this can cause cancer signaling pathways to
also activate. Now, this one actually crosses the boundary into
(11:24):
the whole performance enhancing drug territory. So if you're considering
taking this, then you have to be drug streened or
tested or anything like that. You want to be careful
with this one. Now, another one that you've heard of.
I am certain GLP one medications. Yes, these are peptides.
They've changed everything semi gluetide, truzepetide, retrotruetide, or something like
(11:46):
that that's still under investigation. Now. These have large randomized
control trials, clear weight loss benefit data, cardiovascular outcome data
showing improves your cardiac risk profile. They also have a
lot of safety study They don't have a lot of
long term safety studies, but you know, we're getting there. Now.
This is what evidence based peptides look like. Right. We
(12:07):
have these large studies they and then they went through
FDA approval and now people are using them. That's not
what's happening with these other peptides that we just talked about.
So three things have happened the way that I see it,
The GLP one success has legitimized peptides as it should.
Longevity medicine therefore kind of jumped on this and exploded,
and social media is normalizing self injection of these random peptides,
(12:31):
and now peptides are being marketed as natural, targeted, anti aging,
performance enhancing, and anything else that you know sounds buzzworthy,
and many people are just using this before really much
data is exists. It's all based on a hypothesis like
it maybe it may do something. It may cause cancer
or have other huge risks, but we don't know. And
(12:55):
also some big quo issues are there's no standard dosing
because they haven't done the studies. So whether you do
a huge dose or a small dose, you know what
is the correct dose. And anybody who tells you that
they know for certain what it is, they don't know.
We also don't know, you know the online community compounding variability.
What you get from one pharmacies probably different than from another.
(13:17):
There's a high risk of contamination. Could it be disrupting
our hormones? Maybe probably, there's an unknown cancer risk and
an unknown how are immune systems going to respond? Obviously
a risk is an allergic reaction, but it goes beyond that.
Does some of these peptides insight in autoimmune response. Could
(13:40):
it potentially start new autoimmune diseases or flare existing autoimmune diseases.
I mean, the reality is we just don't know. As
promising as some of these peptides may sound, we have
to remember that newde does not automatically mean safe, and
popular certainly doesn't mean that it's scientifically proven. Many of
(14:02):
these compounds are being marketed well ahead of any robust
clinical data, often bypassing, you know, standards that we rely
on to protect our health. When something is injected, ingested,
or used to alter our own bodies physiology, it deserves
the same level of scrutiny we would expect from any
(14:25):
other medical treatment. Cutting corners in the name of optimization
can come at a real cost. So I don't know.
At the end of the day, wellness should never outpace evidence.
It's worth asking are we truly improving our health or
are we just chasing the illusion of a shortcut. Sustainable
health still comes back to fundamentals, you know, good nutrition,
(14:49):
exercising our body, keeping it moving, making sure we're getting
good quality sleep, and just individualized medical care. That's ground
in science. So before jumping the latest trend, I encourage
everyone to just take a step back, make sure you're
asking questions and make sure the choices you're making today
won't become regrets of tomorrow. And with some of these
(15:11):
trendy treatments, we just don't know yet, So I say,
you know, look into peptides and some of these other things,
you know, take them with some caution. And by the way,
that includes the GLP ones. A lot of robust evidence
on GLP one's, which is why they're FDA approved, but
(15:32):
we lack significant long term data, so you know, try
to get back to the basics, making sure that you
are eating the best you can, exercising the best you can,
talking to your doctor about your individualized needs. If you
want to try peptides, try it, but make sure you're
doing it under the guide of a doctor a reputable place,
(15:55):
and certainly don't forego standard recommendation in the quest for wellness.
I'm breccorn a cool Sapphire. Thank you so much for
listening to Wellness on MASS. Be sure to listen to
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