All Episodes

May 27, 2026 71 mins

Imagine throwing away your antidepressants and never needing them again. For about 85% of the people who sit with Dr. Jeff McNairy, that is exactly what happens.

He is the Chief Medical Officer of Rythmia, the world's only medically licensed ayahuasca retreat, and he looks at the most stigmatized corner of mental health through a clinical lens: the chemistry, the screening, the data, and the integration work that decides whether change lasts.

Meet our guest

Dr. Jeff McNairy holds a doctorate in psychology and a master's in public health from UCLA. He ran locked psychiatric units in Pasadena and was administrative director of Passages Malibu before trying plant medicine himself in 2014. For 25+ years he has worked at the intersection of Western psychology and indigenous medicine, and today he runs the medical operation and Costa Rican licensing for Rythmia.

Thank you to our partners Key takeaways
  • Ayahuasca pairs DMT with an MAOI vine so the compound survives digestion and reaches the brain
  • It activates a gene that links the amygdala to the prefrontal cortex, letting stored trauma surface and release
  • About 85% of guests who came off antidepressants to attend never go back on them
  • Rythmia turns away ~22 people a day for SSRIs, benzodiazepines, heart conditions, bipolar 1, schizophrenia, or type 1 diabetes
  • The ceremony is the start, not the finish: every guest gets a free 13-week integration program
  • A "psychosomatic" purge (vomiting, yawning, sweating) is how the body lets go of held emotion
  • Intention plus meditation may drive a real epigenetic effect, per emerging UK research
  • The biggest red flag in plant medicine is a retreat without firm staff-guest boundaries
Episode highlights

00:00 Intro

02:25 What ayahuasca actually is (DMT + MAOI)

05:22 What a week at Rythmia looks like

10:22 How emotions get stored in the body

12:31 85% come off antidepressants and don't go back

17:19 The free 13-week aftercare program

38:41 Foods that pull you out of the medicine

48:51 Testing biological age before and after

51:31 How Rythmia measures success (98%)

53:42 Breaking the hippie stereotype 57:59 When NOT to do ayahuasca

1:05:57 What he's building next

Links Connect with Nick on social media Easy ways to support

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Listen
Watch
Mark as Played

Advertise With Us

Popular Podcasts

Stuff You Should Know
Betrayal Weekly

Betrayal Weekly

Betrayal Weekly is back for a new season. Every Thursday, Betrayal Weekly shares first-hand accounts of broken trust, shocking deceptions, and the trail of destruction they leave behind. Hosted by Andrea Gunning, this weekly ongoing series digs into real-life stories of betrayal and the aftermath. From stories of double lives to dark discoveries, these are cautionary tales and accounts of resilience against all odds. From the producers of the critically acclaimed Betrayal series, Betrayal Weekly drops new episodes every Thursday. If you would like to share your story, you can reach out to the Betrayal Team by emailing them at betrayalpod@gmail.com and follow us on Instagram at @betrayalpod and @glasspodcasts. Please join our Substack for additional exclusive content, curated book recommendations, and community discussions. Sign up FREE by clicking this link Beyond Betrayal Substack. Join our community dedicated to truth, resilience, and healing. Your voice matters! Be a part of our Betrayal journey on Substack.

Dateline NBC

Dateline NBC

Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com

Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2026 iHeartMedia, Inc.

  • Help
  • Privacy Policy
  • Terms of Use
  • AdChoicesAd Choices