HALF-LIVES: The Science Behind Dosing

In this episode of Midlife Mayhem, Joanne breaks down one of the most misunderstood concepts in the supplement and peptide world: half-life — the amount of time it takes for half of a substance to leave your system.

Half-life is the key that determines:

• how often you should take something

• whether a pill works better than an injection

• why weekly injections make sense for some compounds

• and why weekly injections are completely useless for others

With everyone experimenting with B12 injections, peptides, thyroid meds, GLP-1 weight-loss medications, and metabolic enhancers, understanding half-lives is crucial. It is the difference between a protocol that WORKS and one that’s pure wishful thinking.

Joanne walks you through real-life examples — from caffeine to thyroid hormones — then explains why short half-life peptides like 5-Amino-1MQ and SLU-PP-332 must be taken in ways that match their rapid clearance times.

If you want to be your own health advocate, understand your protocols, and stop wasting money on things taken the wrong way… this episode will change how you see every supplement and injectable.

🧪 Key Topics Covered ✔ What “half-life” actually means

• Simple explanation

• Why it determines dosing schedules

• Why clearance time ≠ half-life

✔ Half-lives of everyday substances

• Caffeine: 5–7 hours

• Melatonin: 20–50 minutes

• Nicotine: ~2 hours

✔ Hormones & metabolism examples

• Thyroid (T4): ~7 days

• T3: ~24 hours

• Cortisol: ~90 minutes

✔ GLP-1 medications (Ozempic, Mounjaro)

• Why once-weekly injections make perfect sense

• How the 5–7 day half-life prevents daily swings

✔ The BIG mistake people are making

Joanne exposes the trend of taking fast-clearing peptides or compounds once a week, despite half-lives of 4–6 hours — making the protocol physiologically pointless.

✔ Short half-life peptides

These require consistent dosing for meaningful effect:

• 5-Amino-1MQ → ~4–6 hour half-life

  • Learn more at: www.5amino.com

• SLU-PP-332 → ~4 hour half-life

  • Learn more at: www.slu332.com

Understanding these half-lives helps you choose the correct delivery method and the correct dosing frequency so your results match your intentions.

🔗 Resources Mentioned in This Episode

• 5-Amino-1MQ Information → www.5amino.com

• SLU-PP-332 Information → www.slu332.com

• My new website (still being finished but take a peek!) → www.joannelee.com

📣 Upcoming Programs & Announcements ✨ January Programs Start the 3rd Week of January

If you want 2025 to be the year you take full control of your health, metabolism, and body composition, Joanne’s programs begin again in mid-January. Spots fill quickly — keep your eye on www.joannelee.com for updates.

🔥 The 10-Month Elite Mentorship — Starts March 1

(Originally planned for February, but the new website is taking a little longer — and it needs to be perfect.)

Joanne is inviting 10 women who are ready for a new life experience:

• Not a quick fix

• Not a shortcut

• A 10-month immersive mentorship

• Deep coaching, retreats, advanced training, and complete physiological transformation

• For women whose commitment matches their desire

If this is you… March 1 is your starting line.

More details coming soon on www.joannelee.com