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A Cohort Study of Cervical Screening Using Partial HPV Typing and Cytology Triage

January 30, 20174 min
A Cohort Study of Cervical Screening Using Partial HPV Typing and Cytology Triage Mark Schiffman, Noorie Hyun, Tina R. Raine-Bennett, Hormuzd Katki, Barbara Fetterman, Julia C. Gage, Li C. Cheung, Brian Befano, Nancy Poitras, Thomas Lorey, Philip E. Castle and Nicolas Wentzensen Int J Cancer. 2016 Dec 1;139(11):2606-15. doi: 10.1002/ijc.30375. Epub 2016 Aug 26. Abstract HPV testing is more sensitive than cytology for cervical screening. However, to incorporate HPV tests into screening, risk-stratification ("triage") of HPV-positive women is needed to avoid excessive colposcopy and overtreatment. We prospectively evaluated combinations of partial HPV typing (Onclarity, BD) and cytology triage, and explored whether management could be simplified, based on grouping combinations yielding similar 3-year or 18-month CIN3+ risks. We typed ∼9,000 archived specimens, taken at enrollment (2007-2011) into the NCI-Kaiser Permanente Northern California (KPNC) HPV Persistence and Progress

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