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Individual detection of 14 high-risk HPV genotypes by the PapType test for the prediction of high-grade cervical lesions

July 28, 20165 min
Individual detection of 14 high-risk HPV genotypes by the PapType test for the prediction of high-grade cervical lesions Cuzick J1, Ho L2, Terry G2, Kleeman M2, Giddings M2, Austin J2, Cadman L2, Ashdown-Barr L2, Costa MJ2, Szarewski A2. J Clin Virol. 2014 May;60(1):44-9. doi: 10.1016/j.jcv.2014.02.002. Epub 2014 Feb 14. Review by Mark H. Einstein, MD, MS Interpretation: A recent article published by Cuzick and colleagues in the Journal of Clinical Virology has helped clarify the value of extended HPV genotyping in triage of high-risk HPV (hrHPV) positive women. In addition to routinely assessed HPV 16 and 18, HPV genotypes 11, 31, 33, 35, 45, 51, 52, 56, 58, 59, 66, and 68 were also evaluated as predictors for development of high-grade cervical lesions. The authors evaluated PapType, a commercially available test designed to perform individual genotyping for hrHPV types in a single assay. They compared the rate of hrHPV detection and the accuracy of CIN2+ prediction between PapType a

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