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Journal of Cystic Fibrosis: Microbial Colonization and Lung Function in Adolescents With Cystic Fibrosis

July 31, 20162 min
Microbial colonization and lung function in adolescents with cystic fibrosis Hector A1, Kirn T1, Ralhan A1, Graepler-Mainka U1, Berenbrinker S1, Riethmueller J1, Hogardt M2, Wagner M3, Pfleger A3, Autenrieth I4, Kappler M5, Griese M5, Eber E3, Martus P6, Hartl D7. J Cyst Fibros. 2016 May;15(3):340-9. doi: 10.1016/j.jcf.2016.01.004. Epub 2016 Feb 5. Interpretation: Patients with cystic fibrosis suffer from chronic progressive pulmonary disease, driven by cycles of airway infection and inflammation. Chronic cystic fibrosis lung disease is characterized by bacterial and fungal colonizations that change upon disease progression and patient aging. With intensified antibiotic therapy and longer survival, patients with cystic fibrosis are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study by Hector et al was to assess the association of bacterial and fungal co

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