Focus on Neurology and Psychiatry

Major Depression With Subsyndromal Mania/Hypomania: Implications for Diagnosis and Management

March 2, 201635 min
Host: Matt Birnholz, MD Guest: Trisha Suppes, MD, PhD Guest: Roger McIntyre, MD Guest: J. Craig Nelson, MD Subsyndromal mania/hypomania are prevalent among patients with major depressive disorder (MDD) and are frequently associated with comorbidities, including substance use disorders, panic disorder, poorer long-term clinical outcomes, and suicidality. Additionally, mixed features of mania/hypomania in depression are associated with more depressive episodes and more atypical features of depression. With the increased appreciation of this constellation of symptoms, the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition introduced a “mixed features” specifier for patients with MDD and subsyndromal mania/hypomania. It has been shown that approximately 25% of patients with MDD meet the criteria for the mixed features specifier. The specifier allows clinicians to better tailor treatment for patients, particularly because some patients with mixed fe

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