Dr Cilia Nazef, Infectious diseases Fellow at the University of South Florida Morsani College of Medicine, explores how Pneumocystis jirovecii, a fungal infection typically affecting immunocompromised patients, can also affect patients suffering from hypercortisolism. Dr. Nazef begins by examining different cases of Pneumocystis jirovecii Pneumonia (PJP) in patients with Cushings disease. Next, she further explains the immunologic basis behind how the hypercortisol state induces immunosuppression. Dr. Nazef closes by examining the basis for PJP prophylaxis in Cushings disease patients, and the shortcomings of the current literature in advocating prophylaxis options.
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