In this episode we explore the causes of insulin resistance, and the dietary modifications that may help those with insulin resistance.
We discuss how insulin resistance is a complex metabolic disorder, that goes beyond one single pathway or cause. There is also a discussion on the mechanisms of insulin resistance pathogenesis. Specifically, we talk about the accumulation of ectopic fat. Ectopic fat is the storage of triglycerides in tissues other than fat tissue, such as the liver, skeletal muscle, heart, and pancreas.
There is also an overview of the Twin-Cycle Hypothesis, which was discussed in more detail in a previous episode with Prof. Roy Taylor. In addition, we give special mention to liver fat accumulation and the relationship between insulin resistance and non-alcoholic fatty liver disease (NAFLD).
Then various diet interventions are assessed for their potential usefulness to those with insulin resistnace. This includes different diet types (e.g. whole-food plant-based diet, low-carbohydrate ketogenic diet, etc.), role of macronutrients, pre-loading studies, and the role of meal timing and circadian effects.
Find the show notes at https://sigmanutrition.com/episode385
Dr. Death: Miracle Man
Paolo is a smart and handsome surgeon, renowned for his ability to perform surgeries that transform his patients’ lives. When television producer Benita covers him for a story, he’ll transform her life too, but not in the ways she expects. As Benita crosses professional lines to be with him, she learns how far Paolo will go to protect his secrets. And halfway around the world, four doctors at a prestigious medical institute make shocking discoveries of their own that call everything into question. From Wondery comes Season Three of the hit podcast, Dr. Death. MIRACLE MAN tells the story of a globe-trotting surgeon who seduces the medical world, and sweeps one woman off her feet. Hosted by Laura Beil. Dr. Death Season 3: Miracle Man is available now to Wondery+ subscribers early and ad-free. New episodes come out weekly, every Tuesday, for free.
This is what the news should sound like. The biggest stories of our time, told by the best journalists in the world. Hosted by Michael Barbaro. Twenty minutes a day, five days a week, ready by 6 a.m.
Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations.