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June 19, 2025 β€’ 61 mins

Rick Wierenga is creator of PyLabRobot, an open-source, hardware-agnostic Python SDK that's lowering the barriers to lab automation for scientists, startups and hackers.

See below for episode links, chapters, and our socials. Hosted by Nabil Laoudji.

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Episode Links:

Chapters:

  • (00:00) - Preview & Introduction
  • (03:33) - Rick's Serendipitous Foray Into Lab Automation
  • (07:00) - Why AWS for Biology
  • (09:17) - Understanding Liquid Handling Robots
  • (10:49) - Generic Robotics Stack
  • (13:20) - Robot Automation With PyLabRobot
  • (15:07) - The Community Building PyLabRobot
  • (16:54) - Why A Big Pharma Would Support PyLabRobot
  • (18:36) - PyTorch: An Open Source Inspiration
  • (20:32) - Sharing Technology In A Competitive Industry
  • (23:11) - Supported Device Ecosystem
  • (25:49) - Surprises in Device Integration
  • (27:54) - Reverse Engineering 101
  • (31:26) - How Useful Are Github CoPilot, Codex, LLMS for Reverse Engineering
  • (34:34) - How Device Manufacturers, Automation Experts, Are Reacting to PyLabRobot
  • (39:17) - Open Source Efforts and Device Safety
  • (41:11) - How PyLabRobot Enables Sharing Protocols, Reproducibility
  • (45:03) - Creating a 3D Scanner From a Liquid Handler
  • (48:49) - Supporting Self-Driving Labs
  • (54:49) - How PyLabRobot Will Evolve
  • (55:40) - Automating Flow Cytometry
  • (58:17) - How To Contribute and Connect

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