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October 9, 2025 32 mins

In this episode, Professor Mal Hopwood and Professor Colleen Loo discuss the introduction of esketamine to the Pharmaceutical Benefits Scheme (PBS) in Australia. They explore the mechanism of action of esketamine, its clinical trials, practical applications, treatment protocols, costs, safety monitoring, and the importance of informed consent. The conversation emphasises the need for proper patient expectations and long-term treatment considerations in managing treatment-resistant depression.

Professor Mal Hopwood is the Ramsay Health Care Professor of Psychiatry at the University of Melbourne and the Director of the Professorial Psychiatry Unit at the Ramsay Clinic Albert Road (RCAR). A former President of the RANZCP, he is a dedicated researcher and clinician specialising in mood disorders and PTSD. He leads an active clinical trials group at RCAR, including in the area of psychedelic treatment.

Professor Colleen Loo is a psychiatrist, Australian National Health and Medical Research Council Leadership Fellow, and Professor of Psychiatry at the University of New South Wales and the Black Dog Institute in Sydney. She is a clinical and research expert in electroconvulsive therapy, transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and ketamine. She is now also researching psychedelic-assisted therapy.

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Disclaimer:
This podcast is provided to you for information purposes only and to provide a broad public understanding of various mental health topics.  The podcast may represent the views of the author and not necessarily the views of The Royal Australian and New Zealand College of Psychiatrists ('RANZCP'). The podcast is not to be relied upon as medical advice, or as a substitute for medical advice, does not establish a doctor-patient relationship and should not be a substitute for individual clinical judgement.  By accessing The RANZCP's podcasts you also agree to the full terms and conditions of the RANZCP's Website. Expert mental health information and finding a psychiatrist in Australia or New Zealand is available on the RANZCP’s Your Health In Mind Website.

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