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September 11, 2026 • 15 mins

Nutrition Nugget! Bite-sized bonus episodes offer tips, tricks and approachable science. This week, Jenn is talking about Retatrutide, the third-generation injectable making waves as the most powerful weight-loss drug studied yet. It targets three hormone pathways at once instead of just one or two, and early trial participants have lost staggering amounts of weight, some over 30 percent of their body weight. But is more always better? Jenn breaks down how this triple mechanism works in the body, what the research shows so far, and why it might finally help the roughly 10 percent of people who never responded to earlier GLP-1s. Still, she has been raising the same concerns since Ozempic first came onto the scene, and this new drug is no exception. Is Retatrutide the breakthrough the weight loss world has been waiting for, or just a stronger version of the same unanswered questions? Tune in to hear Jenn's full take. Like what you're hearing? Be sure to check out the full-length episodes of new releases every Wednesday. Have an idea for a nutrition nugget? Submit it here:https://asaladwithasideoffries.com/index.php/contact/

RESOURCES:

Become a Happy Healthy Hub Member

Jenn’s Free Menu Plan

A Salad With a Side of Fries

A Salad With A Side Of Fries Merch

A Salad With a Side of Fries Instagram

Ozempic

American Diabetes Association

Retatrutide—A Game Changer in Obesity Pharmacotherapy - PMC

Glucagon | Hormones

International Journal of Molecular Sciences

Hyperglycemia vs. Hypoglycemia: Differences in Causes and Symptoms - GoodRx

Glucagon Control on Food Intake and Energy Balance - PMC

Lilly Phase 3 Study

Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials - ScienceDirect

Lilly - Retatrutide

What Is Osteoarthritis? Causes, Symptoms, and Treatments - GoodRx

Potential Retatrutide Benefits You Should Know About - GoodRx

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