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September 15, 2025 28 mins

We’ve all seen it—or maybe we’ve been told we do it: twitching, jerking, or kicking in the night. But when does this common sleep quirk cross the line into a diagnosable condition? In this episode, we will:

  • Define Periodic Limb Movement Disorder (PLMD) and explain how it differs from simple nighttime movements
  • Explore its surprising prevalence in both adults and children—and its strong ties to Restless Legs Syndrome
  • Review leading theories of cause, from dopamine to iron to spinal generators
  • Highlight intriguing new research, including cardiovascular links and AI-based detection
  • Discuss treatment strategies—from iron replacement to dopaminergic medications and lifestyle approaches

Produced by: Maeve Winter

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