Winner of the iHeartRadio Podcast Award for Best Curiosity - If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks then look no further. Josh and Chuck have you covered.

How Nicotine Works

May 31, 201135 min
Sure, nicotine doesn't cause cancer, but it does rearrange the brain's reward system. Humans have been ingesting this plant for more than 6,000 years, but we generally understood little of it. Join Chuck and Josh as they explain how nicotine works.Learn more about advertising on the HowStuffWorks podcasts at to learn about your ad choices when listening to podcasts, visit