Millions of Americans Over 55 Live with Cardiovascular Risk — A Once-Daily Pill May Help Lower That Risk by Reducing Arterial Inflammation and Plaque Buildup. Doug spoke with Dr. Matthew Budoff, Cardiologist and Program Director at Harbor-UCLA Medical Center. Findings from the EKSTROM trial show that low-dose colchicine, when added to standard treatments like statins, helped reduce total plaque volume and demonstrated signs of reversing certain types of buildup inside the heart’s arteries in patients with stable coronary disease.