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August 19, 2026 β€’ 22 mins

Vaginal and urinary symptoms are common during perimenopause and menopause—but understanding why they happen and how different forms of estrogen work can be confusing.

In Episode 8 of this hormone series, Dr. Brendan McCarthy breaks down the relationship between systemic estrogen, vaginal estrogen, estradiol, estriol, testosterone, and the genitourinary symptoms many women experience during menopause.

He discusses:

  • Why oral estrogen doesn't necessarily reach every tissue in the body the way you might expect
  • The difference between systemic and vaginal estrogen
  • Why vaginal estrogen can be an important medical intervention—not simply a "cream"
  • How estrogen can affect vaginal tissue, pH, and urinary health
  • The role of androgens like testosterone in vaginal and genitourinary health
  • What we know—and still don't know—about vaginal estrogen transfer to a partner
  • Why informed consent means truly understanding your treatment
  • Questions you can ask your provider about your hormone therapy and monitoring

Dr. McCarthy's goal is simple: to give women unbiased information so they can feel more informed, curious, and confident when making decisions about their health.

This episode is for educational purposes only and is not a substitute for individualized medical advice. Talk with your healthcare provider about what treatment approach is appropriate for you.

πŸ“š Download the free research resources and citations: Visit www.protealife.com for episode notes, references, and educational materials.

Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more.

If you’re ready to take your health seriously, this podcast is a great place to start.

πŸ‘‡ Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.

πŸ“˜ Read Dr. McCarthy’s Book: Jump Off the Mood Swing – A Sane Woman’s Guide to Her Crazy Hormones https://www.amazon.com/Jump-Off-Mood-...

πŸ“² Follow Dr. McCarthy: Instagram: @drbrendanmccarthy TikTok: @drbrendanmccarthy Website: www.protealife.com

πŸ’¬ Got a question or topic for a future episode? Let us know in the comments! 

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