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April 22, 2021 31 min
Migraines are one of the world’s most common health conditions. It is also the most common neurological disease. Roughly 39 million people in the United States and 1 billion people worldwide suffer from migraines. This makes migraines the third most common debilitating disorder, often resulting in multiple severe headaches a month. In this episode of Physician's Weekly, Peter Hofland, Ph.D., talks with Shelly Reynolds, one of Physician’s Weekly’s correspondents, about the results of a study published in the April 21, 2021, online issue of Neurology®, the journal of the American Academy of Neurology (AAN), which links migraines to an increased risk of high blood pressure after menopause. [1]

Hofland and Reynolds also talk about the results of a study published in the April 21, 2021 edition of JAMA Dermatology, which suggests that the dangers posed by and air pollution – and in particular wildfire smoke - may also extend to the skin.[2]

Also in this edition:
- Paul Smidt talks with Namoi Lopez, Director of Healthcare Policy for the Goldwater Institute about the impact of a pause in the use of Janssen COVID-19 Vaccine rerecommended by the Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC).
- Rachel Giles, MD spoke with Patrick Forde, M.B.B.Ch, Director, Thoracic Oncology Clinical Research Program and Associate professor at Sidney Kimmel Comprehensive Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University in Baltimore, about the results of the Checkmate 816 trial presented during Week 1 of the virtual Annual Meeting of the American Association for Cancer Research (AACR), held April 10-15, 2021. [3]
- Finally, a new study published in the Journal of the American Geriatrics Society has found that listening to music can help older adults sleep better. Researchers from the National Cheng Kung University Hospital in Taiwan combined the results of past studies to understand the effect that listening to music can have on the quality of older adults' sleep.[4]

Clinical trials
A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) (CheckMate 816) - NCT02998528

Highlights of prescribing information
Nivolumab (Opdivo®; Bristol-Myers Squibb)

[1] MacDonald CJ, El Fatouhi D, Madika AL, Fagherazzi G, Kurth T, Severi G, Boutron-Ruault MC. Association of Migraine With Incident Hypertension After Menopause: A Longitudinal Cohort Study. Neurology. 2021 Apr 21:10.1212/WNL.0000000000011986. doi: 10.1212/WNL.0000000000011986. Epub ahead of print. PMID: 33883242.
[2] Fadadu RP, Grimes B, Jewell NP, Vargo J, Young AT, Abuabara K, Balmes JR, Wei ML. Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch. JAMA Dermatol. 2021 Apr 21. doi: 10.1001/jamadermatol.2021.0179. Epub ahead of print. PMID: 33881450.
[3] Forde PM, Spicer J, Lu S, et al. Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment (tx) for resectable (IB-IIIA) non-small cell lung cancer (NSCLC) in the phase 3 CheckMate 816 trial. Presented at: AACR Annual Meeting; April 10-15, 2021; Virtual. Abstract CT003.
[4] Chen CT, Tung HH, Fang CJ, Wang JL, Ko NY, Chang YJ, Chen YC. Effect of music therapy on improving sleep quality in older adults: A systematic review and meta-analysis. J Am Geriatr Soc. 2021 Apr 20. doi: 10.1111/jgs.17149. Epub ahead of print. PMID: 33880759.
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