The Dr. Gabrielle Lyon Show

In a powerful episode of the Dr. Gabrielle Lyon show, I sit down with my mentor, Dr. Donald Layman, to directly address some of the most common protein myths. We react to a controversial clip from the Huberman Lab podcast with Dr. Christopher Gardner, offering a different perspective on the conversation about protein intake, metabolic science, and dietary guidelines.

Dr. Layman, a pioneer in protein research, breaks down the outdate...

In this groundbreaking episode, Dr. Gabrielle Lyon sits down with Dr. Tobias Kohler, a professor of urology at the Mayo Clinic, to discuss a topic most people are afraid to talk about: men's sexual health.

Dr. Kohler shares eye-opening insights, backed by over two decades of clinical experience and research, on the powerful link between foundational health habits and male sexual function. They reveal why erectile dysfunction is a cr...

Are you struggling to get a good night's rest?

Do you think you can thrive on just a few hours of sleep? In this eye-opening episode, Dr. Gabrielle Lyon sits down with renowned sleep scientist Dr. Rebecca Robbins to debunk the biggest sleep myths and reveal the profound connection between sleep and your health, longevity, and daily performance. They dive into the science of sleep, from the homeostatic sleep drive to the crucial role...

Mysterious symptoms. Confusing diagnoses. Years of being dismissed.

In this episode, Michelle Shapiro joins me to unpack the often misunderstood and overlooked world of mast cell activation syndrome (MCAS), histamine intolerance, postural orthostatic tachycardia syndrome (POTS), and hypermobility conditions.

Drawing from her own health journey and experience with thousands of clients, Michelle unpacks why conventional medicine ofte...

Heart disease is the leading cause of death for women—yet it's still treated like a man’s disease. In this powerful conversation, Dr. Martha Gulati, a cardiologist and pioneer in women’s cardiovascular health, exposes the systemic gaps that leave women underdiagnosed, undertreated, and often unheard. Together, we unpack the critical differences in how heart disease presents in women, why standard diagnostic tools fall short, and wh...

Muscle health isn’t just about how much protein you eat—it’s about how your body uses it. And for people with obesity or advancing age, that process can become less effective, even with optimal nutrition.

In this episode, I am joined by Dr. Nick Burd, one of the world’s leading researchers in muscle metabolism, to unpack the concept of anabolic resistance—when muscle doesn’t respond normally to protein and/or exercise. Together, we...

Did you know every 40 seconds someone in the U.S. has a heart attack—and 1 in 5 never even see it coming? This week, I am joined by preventive cardiologist Dr. Michael Twyman as we discuss cutting-edge diagnostics, the endothelial glycocalyx, nitric oxide biology, and why muscle mass is your heart’s best friend. Learn the practical steps and questions to ask to protect your heart before symptoms appear.

Together, we explore:

• Why ...

In this episode, I’m joined by journalist and author Michael Joseph Gross, whose book, Stronger: The Untold Story of Muscle in Our Lives, reveals the powerful and often overlooked role of muscle in human health and society—tracing its importance from ancient civilizations to modern science. We explore how our understanding of muscle has evolved through history, from symbols of strength and vitality in antiquity to current misconcep...

In this episode, Dr. Alexis Wood, a leading researcher at Baylor College of Medicine, joins me to unpack insights into childhood nutrition, genetics, and cognitive health. Dr. Wood's work bridges genetics, dietary practices, and brain development, highlighting how early-life nutrition can shape lifelong outcomes. We explore cutting-edge research, practical strategies for parents, and the surprising factors influencing children's co...

In this episode, I sit down with Dr. David Klurfeld—longtime USDA scientist and one of the few insiders to publicly challenge the WHO's classification of red meat as a carcinogen. We go deep into the flawed evidence behind the infamous 2015 IARC report, why nutritional epidemiology often fails to prove causality, and how a small group of researchers helped shape global policy with low-quality science. If you've ever felt confused a...

Dr. Larry Lipshultz. is one of the world's leading experts in men's reproductive health. In this week's episode, we discuss testosterone therapy, male fertility, and the hidden environmental factors threatening men’s health. Dr. Lipshultz shares groundbreaking insights into why male fertility is declining, common myths surrounding testosterone and prostate cancer, and innovative strategies to safely enhance men's reproductive and o...

What if your biggest challenge isn’t motivation but missing structure? In this episode, I sit down with Brian Johnson to unpack the science and philosophy of lasting behavior change. We explore the power of ancient wisdom, stoicism, and the neuroscience of excellence, and why most wellness apps fail to deliver real transformation.

Brian shares his personal journey from startup success to creating a global movement around character, ...

When it comes to performance, more isn’t always better. In this episode, I sit down with conditioning expert Joel Jamieson to explore the science of recovery, aerobic fitness, and how to use heart rate variability (HRV) to train smarter. They dive into why elite athletes recover so quickly, the long-term value of zone 2 training, and how HRV reflects your resilience—not just your readiness. Joel shares lessons from two decades of w...

In this episode, I’m joined by Dr. Ty Beal—global nutrition researcher and Senior Technical Specialist at the Global Alliance for Improved Nutrition (GAIN)—to uncover the hidden epidemic of micronutrient deficiencies worldwide. From food access and affordability to ultra-processed diets and nutrient bioavailability, we explore how modern food systems are failing billions and what needs to change to truly make the world healthier.

We...

In today's episode, I had the chance to speak to muscle physiology researcher and science communicator Dr. Lauren Colenso-Semple. Together, we unpack the common claims around hormones and training—from whether you should change your workouts based on your cycle, to the real effects of fasted cardio and birth control on performance and muscle growth. We also explore how menopause affects body composition, what the science actually s...

In this episode, I’m joined by Dr. Abbie Smith-Ryan—one of the leading researchers in exercise physiology and women’s metabolism—to unpack the science of how women should be training through perimenopause, postmenopause, and beyond. We dive into the physiological changes that impact body composition, performance, and recovery—and how to adjust training and nutrition to match.

We discuss:

• How high-intensity interval training (HIIT...

This week in the studio, I'm joined by Dr. Nick Barringer—Army Ranger, performance nutrition expert, and one of the sharpest minds in military and metabolic health. Together, we cut through the noise around today's most controversial nutrition topics. If you’ve ever felt whiplash trying to make sense of conflicting headlines, this episode is your science-based compass.

What’s really going on with artificial sweeteners like sucralose...

In this episode, I’m joined by Shaun Noorian—engineer, entrepreneur, and CEO of Empower Pharmacy, the largest compounding pharmacy in the world. With compounded GLP-1s making headlines and lawsuits from Big Pharma intensifying, Shaun joins me to pull back the curtain on the regulatory, financial, and ethical storm brewing behind the scenes.

Are compounded GLP-1s legal? Safe? Who controls drug pricing in the U.S., and why are America...

In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex cond...