This Podcast Will Kill You

An accurate diagnosis can give us so much. It can give us a path forward. It can give us answers to long-standing questions. And it can give us much-needed hope. Yet many people around the world wait years to receive an accurate diagnosis, which can take a profound physical and emotional toll. What underlies these missed or incorrect diagnoses, and what can we do about it? In this week’s TPWKY book club episode, health journa...

It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car, or into the airplane sick bag), barfing up your breakfast. Motion sickness. We’ve all been there, or at least most of us have. Why? What is it about our physiology that breaks down as soon as we travel via wa...

Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year, and its distribution is growing. In this episode, we dissect this abundant fungus, examining how it makes us sick, who tends to get sick, and what we can do about it. We also take you through the history of this fungus, a story that ...

In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So feared and so stigmatized was syphilis that it was sometimes called “the secret disease.” A diagnosis would not only sentence you to a drawn-out and painful illness possibly resulting in death, it also labeled you as an outcas...

If you’ve come across the latest dietary guidelines, a few things may have caught your attention: a big ol’ steak front and center in the new “inverted pyramid”, beef tallow and butter recommended as “healthy” fats, a declaration that the war on protein is ending. “Since when have we been at war with protein?” you may reasonably ask. In part 2 of our episodes on dietary g...

Over the decades, dietary guidelines have taken a diverse array of shapes, from pamphlets to wheels, from plates to pyramids. In many cases, the shapes have changed more than the recommendations they contain. This week and next, we explore those recommendations - who’s making them, how they have changed over time, and how closely they align with what we should be eating. First, we delve into the long history of d...

Why do we believe what we believe? Is what we believe the truth? How can we convince others of our beliefs? If you’ve ever found yourself pondering these questions, you know that the answers are rarely clear-cut. We need to form beliefs in order to navigate the world, but how skilled are we at evaluating evidence for those beliefs or weighing new data that contradicts them? In this week’s TPWKY book club episode, Adam K...

Tear gas is an expected, normalized part of protests today. But its use in international war is banned. How can that be? That’s just one of the questions we investigate in this episode. First, we take you through the long history of tear gas and its emergence alongside deadlier chemical weapons before discussing how its use became routine, fueled by industry interests. Then we delve into what’s in tear gas that causes t...

Though discovered relatively recently, Oropouche virus has been making headlines as an emerging vector-borne infectious disease on the rise. Not transmitted by the usual suspects (like ticks and mosquitoes), this virus is instead spread through the bites of midges or no-see-ums. Since these arthropods are already widely distributed and their range is growing thanks to climate change, this is a recipe for potential disaster. In this...

For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re u...

A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple notebooks to delineate all of the various therapies currently in development. It is nothing short of a revolution. Of course, no revolution is perfect, and many cancer treatments are ineffective or carry risks of serious side eff...

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppress...

Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a cell cancerous are those that, under other circumstances, are beneficial, essential even, for an individual’s growth and survival. How is that possible? In the second installment in our series, we’re putting cancer unde...

Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowledge that will help make sense of this multifaceted disease. We begin our four-part series on cancer by asking a deceptively simple question: what is cancer? As we’ll discover over the course of these episodes, there is not one ans...

What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” experiments from the mid-20th century revealed a behavioral dark side that emerged as space grew increasingly limited, ultimately leading to complete population collapse. As headlines conveyed dire warnings about globa...

Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate sewer systems have revolutionized health and hygiene by whisking our poop far away where we don’t have to think about it. But that poop has gotta go somewhere, and eventually, not thinking about it isn’t going to be ...

It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so, we’re going to bring it back into mind as we delve into the rich world of poop. This episode, the first of a two-part miniseries on poop, features a wide cast of characters all with some role in the production or ma...

For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from how they taste to what we eat, refrigeration has dramatically - and quite recently - changed our relationship to food, our health, and the environment. As Nicola Twilley describes in Frostbite: How Refrigeration Changed ou...

Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to public health guidelines. Why is that? Hypotheses abound, but many point the finger of blame at different aspects of modern society such as screen time, artificial light, a sedentary lifestyle. These narratives suggest that sleep in...