What Could Go Right?

What Could Go Right?

It's easy to be pessimistic, especially with headlines dominated by global challenges like a changing geopolitical landscape, the rise in authoritarianism, and a seemingly unstable global economy. But what if, despite all that, humanity is actually making progress?Join Progress Network Founder Zachary Karabell every Wednesday as he chats with leading experts like Ian Bremmer and Anne Marie Slaughter to challenge the negativity and find out whether we should be so pessimistic about everything from sustainability and polarization to the future of work. Plus, start your week right with Progress Network Executive Director Emma Varvaloucas, who delivers a weekly dose of essential good news every Monday. If environmental success stories and medical breakthroughs are your thing, you won’t want to miss it.Tune in to discover the evidence for progress and find your reason for cautious optimism.

Episodes

May 20, 2026 52 mins
Why does historic abundance breed widespread cultural anger? Nick Gillespie, editor-at-large of Reason Magazine and host of the Reason podcast, joins host Zachary Karabell to unpack the great conundrum of the 21st century: why humans have more security and financial means than ever before, yet feel increasingly dissatisfied. In a world deeply divided along absolute binary lines, Gillespie explains how a philosophy of libertarianism...
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France just passed a landmark law allowing the return of cultural artifacts taken from nations during the colonial era — a long-overdue step nearly a decade in the making.  Plus: all 50 U.S. states have now enacted rape kit reform, cutting the national backlog in half; violent crime in major American cities is falling faster than you might expect; and a new drug is doing something doctors have never been able to say about ALS — it...
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What happens when our biological need for certainty clashes with an increasingly unpredictable world? Simone Stolzoff, author of How to Not Know, joins host Zachary Karabell to discuss why our modern intolerance for uncertainty is fueling a global anxiety crisis. Rather than seeing the unknown as a threat, Stolzoff argues that uncertainty is the fundamental birthplace of scientific breakthroughs, original art, and human progress. ...
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Gene therapy has been quietly pulling off miracles, and this week, it got its Oscars moment. Emma Varvaloucas, Executive Director of The Progress Network, breaks down how a husband-and-wife scientific team's decades-long quest has restored sight to over 100 blind Americans, and how a brand-new drug called Otarmeni just became the first-ever FDA-approved gene therapy for genetic deafness. The science is extraordinary. The price tags...
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What happens when the global energy supply faces its greatest disruption since the 1970s? Jason Bordoff, a leading energy expert and former advisor in the Obama White House, joins host Zachary Karabell to navigate a world where the Strait of Hormuz is closed and gasoline prices are soaring.   The conversation moves past the immediate panic at the pump to look at the future of how we power our lives. Bordoff shares personal stories...
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For the first time in over a century, renewables have knocked coal out of the top spot for global electricity generation — and solar is the reason why. Emma Varvaloucas, Executive Director of The Progress Network, breaks down what this energy milestone actually means, and why geopolitics is unexpectedly accelerating the clean energy transition. Plus: forty years after the worst nuclear disaster in history, wildlife is flourishing ...
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What happens when the person building the world's most powerful technology is just as worried about it as we are? Sebastian Mallaby, the Pulitzer Prize-nominated author of The Infinity Machine, joins host Zachary Karabell to pull back the curtain on Demis Hassabis, the founder of DeepMind who is currently leading the global charge into artificial intelligence. From the "Ender’s Game" mission that drives Hassabis to the chilling lo...
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Trump just signed an executive order to fast-track psychedelic medical research. Emma Varvaloucas, the Executive Director of The Progress Network, breaks down how a 50-year political taboo went mainstream. Plus: San Diego achieves water independence and starts brewing beer from recycled sewage, a humpback whale stampede breaks a sighting record off South Africa, and gene-edited bananas that don't turn brown are finally here.What Co...
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What happens when the rules of the global game are being rewritten in real-time? Ian Bremmer, the founder of Eurasia Group and GZERO Media, joins host Zachary Karabell to discuss how to navigate a world defined by a "long geopolitical recession" and the erosion of the post-1945 order. From the escalating conflicts in the Middle East and the surprising vulnerabilities of the economic models in the Gulf to the "asymmetric war fighti...
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Hungary just voted out its authoritarian prime minister of 16 years, and did it with an 80% voter turnout powered by Gen Z. Emma Varvaloucas, the Executive Director of The Progress Network, breaks down how they pulled it off and what it means for democracies under pressure elsewhere.  Plus: over 10% of the world's oceans are now protected, US rents are finally dropping, and Thailand just criminalized online sexual harassment, incl...
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What do we do when our systems stop working? Anne-Marie Slaughter, the CEO of New America, former Director of Policy Planning at the U.S. State Department under Secretary Hillary Clinton, and one of the most influential voices in American foreign policy joins Zachary Karabell to reckon with a country in the middle of a massive realignment. From democratic reform and the collapse of the two-party system to America's fraying role on...
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October 8, 2025 54 mins
Let’s close out Season 7! Zachary and Emma look back on seven months of thought-provoking positive conversations, from global politics to the depths of sci-fi, exploring how to stay hopeful in a world hooked on negative news. They dive into protecting your mental health by controlling your news intake while also celebrating how social media platforms empower 8 billion voices to be heard!What Could Go Right? is produced by The Progr...
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Get ready for a Progress Report season finale packed with good news as Emma shares some life-changing breakthroughs! The Gates Foundation is funding a game-changing GBS vaccine, while a cutting-edge AI stroke diagnosis system in England is significantly improving recovery rates. Plus, China steps up with a bold pledge to slash greenhouse gas emissions while NASA’s James Webb Telescope just uncovered an astonishing 6,000 new planets...
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It’s time for a lesson in civics! Zachary and Emma are joined by Nick Capodice, co-host of the Civics 101 podcast where he gets into the basics of how the U.S. government works and also helps teachers design lesson plans to pair with the show. Nick highlights how our collective grasp on how things work in Washington is slipping, the decrease of civics education funding since the 1950s, and the recent rise of deep divisions in Ameri...
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Emma brings you a solo edition of the Progress Report, highlighting several positive global advancements. Brazil goes bold with a two-part strategy against dengue fever, involving both a homegrown vaccine and specially bred mosquitoes that carry an anti-dengue bacteria. Africa is leading a major expansion of school meal programs for children. And around the world we have two stories of security, with the High Seas Treaty recently r...
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Can today’s science fiction become tomorrow’s guidebook for change? Zachary and Emma sit down with Ed Finn, the visionary behind the Center for Science and the Imagination at ASU and academic director of Future Tense. Ed explores the intersection between sci-fi and real world science, the complexities of new technologies like AI and gene editing, and why our imaginations can be the launchpad for tomorrow’s innovations and building ...
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Get ready for another uplifting Progress Report! This week, Zachary and Emma bring you inspiring stories of innovation and hope from across the globe. Trekkies rejoice as Apple’s new AirPods push tech into sci-fi territory with real-time language translation, Europe is seeing fewer flood fatalities and less damage thanks to cutting-edge warning systems and disaster response improvements, and France just made history by launching th...
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How do we protect America’s wild open spaces while meeting the demands of conservation, recreation, and development? Zachary welcomes Josh Jackson, author of The Enduring Wild: A Journey Into California's Public Lands. Founder of the Forgotten Lands Project, Josh aims to connect people with these landscapes through immersive storytelling and experiences. He explores the Bureau of Land Management’s role in sustaining the health of 2...
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What really went wrong with global politics? Emma welcomes Brink Lindsey, Senior VP at the Niskanen Center and author of The Captured Economy: How the Powerful Enrich Themselves, Slow Down Growth, and Increase Inequality. Lindsey traces how politics, culture, and economics became unstable, from the development of liberal capitalism since the 1990s to the resulting rise of right-wing populism. He explores the contradictory ways this...
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September 3, 2025 50 mins
How can parents use data without becoming overwhelmed by getting things right and wrong? Zachary and Emma welcome Emily Oster, a professor of economics and author of several data-driven parenting and pregnancy books, including Expecting Better: Why the Conventional Pregnancy Wisdom Is Wrong and What You Really Need to Know. Known for her data-driven approach to parenting and pregnancy, Oster shares how she accidentally became the c...
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