Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
Of when my doctors come in the fifty five case
morning show OHC the cancer Specialist, my cancer doctors from
my lymphoma. Thank God I don't have coalorectal cancer, but
apparently I may very well be able to get it
in studio. One of the awesome doctors at OHC, doctor
Mark Johns, who is a medical oncologist and hematologist who
treats solid tumors, including corectal cancer, through standard and ground
(00:23):
baking treatment options offered at OHC, including clinical trials which
we'll probably hear about this morning. He's the principal investigator
for gastro Intestinal, prostate and genito urinary clinical trials at OHC.
Strongly believes in the power providing our patients with the
latest revolutionary therapies available. That's a theme at OHC, and
I've gotten wonderful treatment there. Welcome to the studio. It's
(00:44):
a pleasure to have you in here, doctor John's.
Speaker 2 (00:46):
Thanks for having me.
Speaker 1 (00:47):
All right? Why are we seeing more corectal cancer in
younger people? And I had asked you off air and
you told me to at least bring it up on air,
so here I am. Is it possible that it's the
vast amount of ultra processed fast food duds. And I
was telling you about when I was a kid. You
can easily draw a contrast between what it was like
in nineteen seventy five and here we are in twenty
twenty five. I have like nine thousand more fast food
(01:10):
alternatives and it's all ultra processed. Is that part of it?
Speaker 2 (01:14):
So that's a great question. Every year you ask me,
and every year we say, it's something in the microbiome,
it's something in the diet, it's something in our lifestyle,
and we can never really put our finger on it,
and we still don't quite know the answer. But I
did find something interesting and something I wanted to share
with you. There was a study that was presented at
ASCO got a standing ovation and then was published in
(01:37):
the New England Journal of Medicine this summer, and I
thought i'd share it with you. It's called the Challenge Study.
And what the investigators in the Challenge Study showed is
they took patients with the high risk colon cancer, so
colon cancer that had spread to the lymph nodes already primarily,
and everybody had surgery, everybody had standard of care con
(02:00):
generation agumate chemotherapy, what we call full fox chemotherapy. Half
the patients they got educational materials, like a pamphlet is
it here you should leave lead a healthy lifestyle. The
other half they were randomized to supervised activities, so an
exercise regimen, and they followed these patients closely. The patients
(02:22):
that exercised they lived longer. And they didn't live longer
because they had fewer strokes and fewer heart attacks. They
lived longer because they had better cancer outcomes. So the
cancer actually showed back up in the liver less often.
Speaker 1 (02:38):
Okay, this is the metastasize. I mean, you haven't the
colon and they be able to cut that out. But
if it metastasized is going everywhere, right.
Speaker 2 (02:48):
So that's the first place that typically goes to is
the liver. And a major risk factor for having colon
cancer is having had it in the past. These patients
developed fewer second colon cancers. The men that got less
prostate cancer, the women they got less breast cancer. How
much less? Okay? Yeah, so when you go back with
(03:09):
first generation chemotherapy, five year disease free survival, so the
chance of being alive without your cancer back it was
about sixty seven percent with first generation chemo, and it
was a revolution when we changed to the second generation
called Fullfox seventy three percent. Now by adding exercise, the
(03:30):
group that just got the pamphlet, they got the same
seventy three percent five year disease free survival with exercise
eighty percent. What that means is that exercise added more
to disease free survival than did the last major evolution
of our actuate chemo therapy rich.
Speaker 1 (03:48):
That's amazing.
Speaker 2 (03:49):
If it was a drug, it would be FD approved.
Everyone needs to get back out there and they need
to start exercising. I think that's part of what's changing.
We've become sedentary anxiety.
Speaker 1 (04:00):
So yeah, ultra process food bad and maybe one of
the reasons you have coll rectal cancer increasing. But obviously
we are so much more sedentary given the computer screen
and existence that we all have.
Speaker 2 (04:13):
Absolutely, and so what they showed here is they sought
to increase activity by what's called ten met hours per week.
A met hour is the amount of energy you burn
just sitting in a chair completely unstimulated for an hour.
To do that, it's just a twenty minute brisk walk
every day.
Speaker 1 (04:33):
And you know what, doctor as I sit here today
and I feel embarrassed because I'm that lazy guy. And
I'm feeling a little concerned about going home today because
my wife regularly listens to the morning show, and I
know I'm going to hear your words to May back
to me when I get home today.
Speaker 2 (04:52):
Thank her for a walk.
Speaker 1 (04:53):
I know, I know, I know, I know. Okay, But
it is the leading cause of all cancer deaths in
men under fifty, and the second leading cause for women
of all cancer deaths. It's corectal cancer. Now, oh, absolutely,
all right? All important? What symptoms should I would think everyone,
(05:14):
but now younger adults be watching for sure.
Speaker 2 (05:17):
We talk about blood in the stool, a change in
the caliber of the stool, abdominal pain, weakness, and fatigue
from anemia. Kind of The important thing to keep in
mind is that you can be completely asymptomatic and have
colon cancer. And that's why screening is so important.
Speaker 1 (05:34):
Okay, and at what well? Younger people are now getting
colorectal cancer at a much younger age. So when does
the screening kick in? Because it used to be what
forty five or fifty.
Speaker 2 (05:44):
It used to be nifty and now we've dropped it
down to forty five years of age. So the incidence
of colon cancer is about ten per one hundred thousand
in the thirties. It's more than doubles by the late forties,
so between forty five and fifty it's probably about twenty
five one hundred thousand, and it keeps going up from there.
Speaker 1 (06:04):
And how often does one need the screening? I know,
mimography is a represented are expected on a certain certain regularity.
So getting the colonoscopy how often?
Speaker 2 (06:15):
Sure? Colonoscopy is every ten years. If you choose to
do colo guard, that's every three years. If you use
the garden shield, that's also every three years.
Speaker 1 (06:29):
In your experience, given your level of expertise as a
cancer specialist, is ten years often enough. How long will
it take for a cancer to actually develop? I mean,
you know, they find a pole up when they're doing
your colonoscopy and they take that out, and that could
turn into a cancer. But I mean, can it pop
(06:50):
up very quickly right after that aggressively?
Speaker 2 (06:52):
I mean it can. But what tends to happen is
that if they don't find anything, they'll tell you ten
years and if you're stuinroologist finds polyps, and they'll bring
you back more quickly. If you have an inherited cancer
syndrome like HNPCC or the Lynch syndrome, it's called a
non polyposis syndrome because apparently the mucosa goes from normal
(07:14):
to invasive cancer very quickly, and so we want to
find those people through genetic testing, and then we do
colonoscopy more frequently, like every one to two years in
those patients.
Speaker 1 (07:24):
Okay, give them my lymphoma. I regularly seeing one of
the OHC doctors, and I get my blood screen several
times a year, and I get ZT scans, and so
they're really right on top of it. But in terms
of blood screening, is that a way of identifying Is
there any blood work that can be done that might
suggest that you need a colonoscopy or that it could
be colorectal cancer? U.
Speaker 2 (07:44):
Yeah. So there's the garden Shield, which is a self
free DNA assay okay, and it is FDA approved for
screening for colon cancer. Has diminished sensitivity for detecting advanced
pre cancerous poll but if you have established invasive cancer,
it's pretty good at detecting that. It's also plagued just
(08:06):
like colon guard with some degree of false positives.
Speaker 1 (08:09):
All right, now, pivoting back to young people, We've already
talked about regular exercise. So that's on the short list
to prevent colorectal cancer. What else is on the short list?
Speaker 2 (08:21):
Avoid cigarettes? Cigarettes increase the risk of colon cancer by
fifty percent. Heavy alcohol increases the risk of colon cancer
by thirty percent. Process meets by twenty percent, Excess red
meats by ten percent. So eat a diet high end fiber,
avoid those, get your screening colonoscopy.
Speaker 1 (08:42):
And alcohol is one of the things that only it
seems to me, and it only recently started being a
focus of cancer when I was young growing up. And
you know, I m'd say, only within the last ten
years have I read that excessive alcohol comes consumption can
cause cancer. Right.
Speaker 2 (08:56):
We used to say, you know, a glass of wine
was okay. Now we've really kind of curtailed that.
Speaker 1 (09:01):
All right, knowing your family history, I see, is is
there a genetic test that OHC offers that helps you
provide that foundation? Oh, we have one we just talked about.
Speaker 2 (09:11):
Yes, yes, so we have genetic testing at OHC. You
do not have to have been diagnosed personally with colon
cancer or any cancer to be tested. You would just
simply give us a call at seven five one, two
two seven three or eight eight eight six four nine
forty eight hundred, or visit our website at oh care
dot com and we can get you in and get
(09:31):
you tested.
Speaker 1 (09:32):
All right, I usually end on it, and so I'll
end on it today, Doctor John's clinical trials. It's usually
where the cutting edge therapies are being offered. I know
you always offer them at OHC. How about for colorectal cancer?
Speaker 2 (09:43):
Oh? Absolutely. We talked about a tumor vaccine last year
that trials closed and we're waiting to see if that
was of any benefit. This year, we have a randomized
FACE two trial of a drug called solictit to zam
ap a diz taken, which is a healthful Okay, what
it is. It's an antibody drug conjugate. It's an antibody
(10:04):
directed towards something called c MET that's present on the
surface of advanced colon cancer cells and it brings the
chemote therapy right to the colon cancer cell. And we're
looking at adding it to standard of care first line
therapy for stage four colon cancer. So if you or
a loved one has been diagnosed with colon cancer that
(10:24):
has spread audifate colon into other parts of your body
and you haven't yet received treatment, we'd love to hear
from you.
Speaker 1 (10:30):
So it acts kind of like a magnet.
Speaker 2 (10:32):
Yeah, absolutely, we have other drugs like that. This drug
is already has an accelerated approval actually a drug similar
in non small cell lung cancer, and we're hoping it
revolutionizes colon cancer the same way.
Speaker 1 (10:44):
Always on the cutting edge of things cancer related. Ohc
foind the on line at OHCA dot com. The number
is eight eight eight six eight hundred for a first
or second opinion eight eight eight sixty eight hundred Doctor
Mark John's thank you for all the valuable information and
keeping this in the front of our minds. And we'll
now have to start thinking about our young people. But
diet and exercise apparently are real key, absolutely
Of when my doctors come in the fifty five case
morning show OHC the cancer Specialist, my cancer doctors from
my lymphoma. Thank God I don't have coalorectal cancer, but
apparently I may very well be able to get it
in studio. One of the awesome doctors at OHC, doctor
Mark Johns, who is a medical oncologist and hematologist who
treats solid tumors, including corectal cancer, through standard and ground
(00:23):
baking treatment options offered at OHC, including clinical trials which
we'll probably hear about this morning. He's the principal investigator
for gastro Intestinal, prostate and genito urinary clinical trials at OHC.
Strongly believes in the power providing our patients with the
latest revolutionary therapies available. That's a theme at OHC, and
I've gotten wonderful treatment there. Welcome to the studio. It's
(00:44):
a pleasure to have you in here, doctor John's.
Speaker 2 (00:46):
Thanks for having me.
Speaker 1 (00:47):
All right? Why are we seeing more corectal cancer in
younger people? And I had asked you off air and
you told me to at least bring it up on air,
so here I am. Is it possible that it's the
vast amount of ultra processed fast food duds. And I
was telling you about when I was a kid. You
can easily draw a contrast between what it was like
in nineteen seventy five and here we are in twenty
twenty five. I have like nine thousand more fast food
(01:10):
alternatives and it's all ultra processed. Is that part of it?
Speaker 2 (01:14):
So that's a great question. Every year you ask me,
and every year we say, it's something in the microbiome,
it's something in the diet, it's something in our lifestyle,
and we can never really put our finger on it,
and we still don't quite know the answer. But I
did find something interesting and something I wanted to share
with you. There was a study that was presented at
ASCO got a standing ovation and then was published in
(01:37):
the New England Journal of Medicine this summer, and I
thought i'd share it with you. It's called the Challenge Study.
And what the investigators in the Challenge Study showed is
they took patients with the high risk colon cancer, so
colon cancer that had spread to the lymph nodes already primarily,
and everybody had surgery, everybody had standard of care con
(02:00):
generation agumate chemotherapy, what we call full fox chemotherapy. Half
the patients they got educational materials, like a pamphlet is
it here you should leave lead a healthy lifestyle. The
other half they were randomized to supervised activities, so an
exercise regimen, and they followed these patients closely. The patients
(02:22):
that exercised they lived longer. And they didn't live longer
because they had fewer strokes and fewer heart attacks. They
lived longer because they had better cancer outcomes. So the
cancer actually showed back up in the liver less often.
Speaker 1 (02:38):
Okay, this is the metastasize. I mean, you haven't the
colon and they be able to cut that out. But
if it metastasized is going everywhere, right.
Speaker 2 (02:48):
So that's the first place that typically goes to is
the liver. And a major risk factor for having colon
cancer is having had it in the past. These patients
developed fewer second colon cancers. The men that got less
prostate cancer, the women they got less breast cancer. How
much less? Okay? Yeah, so when you go back with
(03:09):
first generation chemotherapy, five year disease free survival, so the
chance of being alive without your cancer back it was
about sixty seven percent with first generation chemo, and it
was a revolution when we changed to the second generation
called Fullfox seventy three percent. Now by adding exercise, the
(03:30):
group that just got the pamphlet, they got the same
seventy three percent five year disease free survival with exercise
eighty percent. What that means is that exercise added more
to disease free survival than did the last major evolution
of our actuate chemo therapy rich.
Speaker 1 (03:48):
That's amazing.
Speaker 2 (03:49):
If it was a drug, it would be FD approved.
Everyone needs to get back out there and they need
to start exercising. I think that's part of what's changing.
We've become sedentary anxiety.
Speaker 1 (04:00):
So yeah, ultra process food bad and maybe one of
the reasons you have coll rectal cancer increasing. But obviously
we are so much more sedentary given the computer screen
and existence that we all have.
Speaker 2 (04:13):
Absolutely, and so what they showed here is they sought
to increase activity by what's called ten met hours per week.
A met hour is the amount of energy you burn
just sitting in a chair completely unstimulated for an hour.
To do that, it's just a twenty minute brisk walk
every day.
Speaker 1 (04:33):
And you know what, doctor as I sit here today
and I feel embarrassed because I'm that lazy guy. And
I'm feeling a little concerned about going home today because
my wife regularly listens to the morning show, and I
know I'm going to hear your words to May back
to me when I get home today.
Speaker 2 (04:52):
Thank her for a walk.
Speaker 1 (04:53):
I know, I know, I know, I know. Okay, But
it is the leading cause of all cancer deaths in
men under fifty, and the second leading cause for women
of all cancer deaths. It's corectal cancer. Now, oh, absolutely,
all right? All important? What symptoms should I would think everyone,
(05:14):
but now younger adults be watching for sure.
Speaker 2 (05:17):
We talk about blood in the stool, a change in
the caliber of the stool, abdominal pain, weakness, and fatigue
from anemia. Kind of The important thing to keep in
mind is that you can be completely asymptomatic and have
colon cancer. And that's why screening is so important.
Speaker 1 (05:34):
Okay, and at what well? Younger people are now getting
colorectal cancer at a much younger age. So when does
the screening kick in? Because it used to be what
forty five or fifty.
Speaker 2 (05:44):
It used to be nifty and now we've dropped it
down to forty five years of age. So the incidence
of colon cancer is about ten per one hundred thousand
in the thirties. It's more than doubles by the late forties,
so between forty five and fifty it's probably about twenty
five one hundred thousand, and it keeps going up from there.
Speaker 1 (06:04):
And how often does one need the screening? I know,
mimography is a represented are expected on a certain certain regularity.
So getting the colonoscopy how often?
Speaker 2 (06:15):
Sure? Colonoscopy is every ten years. If you choose to
do colo guard, that's every three years. If you use
the garden shield, that's also every three years.
Speaker 1 (06:29):
In your experience, given your level of expertise as a
cancer specialist, is ten years often enough. How long will
it take for a cancer to actually develop? I mean,
you know, they find a pole up when they're doing
your colonoscopy and they take that out, and that could
turn into a cancer. But I mean, can it pop
(06:50):
up very quickly right after that aggressively?
Speaker 2 (06:52):
I mean it can. But what tends to happen is
that if they don't find anything, they'll tell you ten
years and if you're stuinroologist finds polyps, and they'll bring
you back more quickly. If you have an inherited cancer
syndrome like HNPCC or the Lynch syndrome, it's called a
non polyposis syndrome because apparently the mucosa goes from normal
(07:14):
to invasive cancer very quickly, and so we want to
find those people through genetic testing, and then we do
colonoscopy more frequently, like every one to two years in
those patients.
Speaker 1 (07:24):
Okay, give them my lymphoma. I regularly seeing one of
the OHC doctors, and I get my blood screen several
times a year, and I get ZT scans, and so
they're really right on top of it. But in terms
of blood screening, is that a way of identifying Is
there any blood work that can be done that might
suggest that you need a colonoscopy or that it could
be colorectal cancer? U.
Speaker 2 (07:44):
Yeah. So there's the garden Shield, which is a self
free DNA assay okay, and it is FDA approved for
screening for colon cancer. Has diminished sensitivity for detecting advanced
pre cancerous poll but if you have established invasive cancer,
it's pretty good at detecting that. It's also plagued just
(08:06):
like colon guard with some degree of false positives.
Speaker 1 (08:09):
All right, now, pivoting back to young people, We've already
talked about regular exercise. So that's on the short list
to prevent colorectal cancer. What else is on the short list?
Speaker 2 (08:21):
Avoid cigarettes? Cigarettes increase the risk of colon cancer by
fifty percent. Heavy alcohol increases the risk of colon cancer
by thirty percent. Process meets by twenty percent, Excess red
meats by ten percent. So eat a diet high end fiber,
avoid those, get your screening colonoscopy.
Speaker 1 (08:42):
And alcohol is one of the things that only it
seems to me, and it only recently started being a
focus of cancer when I was young growing up. And
you know, I m'd say, only within the last ten
years have I read that excessive alcohol comes consumption can
cause cancer. Right.
Speaker 2 (08:56):
We used to say, you know, a glass of wine
was okay. Now we've really kind of curtailed that.
Speaker 1 (09:01):
All right, knowing your family history, I see, is is
there a genetic test that OHC offers that helps you
provide that foundation? Oh, we have one we just talked about.
Speaker 2 (09:11):
Yes, yes, so we have genetic testing at OHC. You
do not have to have been diagnosed personally with colon
cancer or any cancer to be tested. You would just
simply give us a call at seven five one, two
two seven three or eight eight eight six four nine
forty eight hundred, or visit our website at oh care
dot com and we can get you in and get
(09:31):
you tested.
Speaker 1 (09:32):
All right, I usually end on it, and so I'll
end on it today, Doctor John's clinical trials. It's usually
where the cutting edge therapies are being offered. I know
you always offer them at OHC. How about for colorectal cancer?
Speaker 2 (09:43):
Oh? Absolutely. We talked about a tumor vaccine last year
that trials closed and we're waiting to see if that
was of any benefit. This year, we have a randomized
FACE two trial of a drug called solictit to zam
ap a diz taken, which is a healthful Okay, what
it is. It's an antibody drug conjugate. It's an antibody
(10:04):
directed towards something called c MET that's present on the
surface of advanced colon cancer cells and it brings the
chemote therapy right to the colon cancer cell. And we're
looking at adding it to standard of care first line
therapy for stage four colon cancer. So if you or
a loved one has been diagnosed with colon cancer that
(10:24):
has spread audifate colon into other parts of your body
and you haven't yet received treatment, we'd love to hear
from you.
Speaker 1 (10:30):
So it acts kind of like a magnet.
Speaker 2 (10:32):
Yeah, absolutely, we have other drugs like that. This drug
is already has an accelerated approval actually a drug similar
in non small cell lung cancer, and we're hoping it
revolutionizes colon cancer the same way.
Speaker 1 (10:44):
Always on the cutting edge of things cancer related. Ohc
foind the on line at OHCA dot com. The number
is eight eight eight six eight hundred for a first
or second opinion eight eight eight sixty eight hundred Doctor
Mark John's thank you for all the valuable information and
keeping this in the front of our minds. And we'll
now have to start thinking about our young people. But
diet and exercise apparently are real key, absolutely
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