October 3, 2025 • 8 mins
- More than 1 billion people worldwide and 12% of Americans live with migraines, a disabling neurological condition that disrupts sleep, work, and daily life
- Melatonin does more than regulate sleep; it also shields your brain at a cellular level by neutralizing damaging free radicals and reducing inflammation linked to migraines
- Research shows melatonin reduces headache frequency by 51%, intensity by 53%, and duration by 46%, offering a powerful natural alternative to standard pharmaceutical drugs
- Adults with episodic migraines taking 3 mg of melatonin before bed experienced the strongest improvements, often cutting their migraine frequency by half or more
- Melatonin’s safety profile is superior to common drugs like amitriptyline, with fewer and milder side effects, making it a well-tolerated option for migraine prevention
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