July 5, 2025 • 7 mins
Story at-a-glance
- Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition where jawbone dies and fails to heal, and it’s been linked to common bone drugs like bisphosphonates and denosumab
- A Finnish study found that people taking denosumab were five times more likely to develop MRONJ than those using bisphosphonates, with cancer patients and long-term users at highest risk
- Adding corticosteroids to bone drugs significantly worsened outcomes, multiplying the risk of jaw disease by up to six times in some users
- MRONJ often begins after dental procedures like extractions, but it also develops in people with gum disease or dentures — even without dental intervention
- Preventive dental care, a nutrient-rich diet, and lifestyle habits that support natural bone repair offer your best defense against this disfiguring and painful condition
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