Story at-a-glance
- A single protein called klotho extended healthy mice lifespan by 20%, while improving muscle strength, bone density and cognitive function across multiple body systems
- Klotho functions as a "longevity switch" that naturally declines with age; it’s influenced by lifestyle choices rather than just chronological aging
- Regular moderate exercise, whole-food diets rich in antioxidants and adequate vitamin D significantly boost klotho levels, while overtraining reverses these benefits
- Poor sleep, chronic stress, loneliness and habits like smoking all decrease klotho production, accelerating the aging process and increasing disease risk
- Scientists are exploring klotho as a biomarker for healthy aging, as low levels correlate with greater risk of cognitive decline, frailty and early mortality
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