Know Thyself

Know Thyself

Know Thyself is a community supporting you to KNOW the true nature of yourself and the world around you, THRIVE in your health, wealth, and relationships – ultimately empowering you to CREATE and share your true self with the world. Each week André Duqum interviews experts in their field; ranging from spiritual educators to cutting edge scientists, heart-led creatives & more on topics such as the true nature of ‘Self’, “what is reality?,” and exploring the fundamental pillars we all need to unlock our fullest potential. Contributing to birthing a more beautiful world, one episode at a time.

Episodes

June 16, 2026 90 mins

Dr. Caroline Leaf is a cognitive neuroscientist and bestselling author who has spent over 40 years studying the relationship between the mind and the brain. At a time when neuroplasticity was still emerging as a field, she was already building clinical tools to help patients recover from brain injuries, trauma, and conditions that conventional medicine had written off as permanent. In this conversation, we go deep into a distinctio...

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Todd Rose is a Harvard-trained social scientist, former high school dropout with a 0.9 GPA, and co-founder of the think tank Populace. His research centers on the gap between what people privately believe and what they publicly say, and the profound consequences of that gap for individuals and for society. This is one of those conversations that reframes something you ...

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This is a compilation episode, and it draws from some of the most honest and clarifying moments across recent conversations on the show. Nine different voices, each approaching the same territory from a different angle: what it means to stop being ruled by the outside world, to understand the patterns we inherited, and to come back to something more real inside ourselv...

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Dr. Vasant Lad is the founder of the Ayurvedic Institute and the man most responsible for bringing Ayurveda to the West. He has spent over 40 years teaching this 5,000-year-old science of life to practitioners across the world, and in this conversation, we sat down together at SoHum Mountain Healing Center in Asheville, North Carolina, where I had just completed a week-long Panchakarma. What unfolded was one of the most quietly pro...

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Dr. Mei Rui is a Yale-trained molecular biophysicist, concert pianist, and clinical researcher at MD Anderson Cancer Center, where she runs trials on the measurable effects of music on the human body. In this conversation, we explore what actually happens in the brain the moment music enters it, why the auditory system is the first sense to develop in the womb and the last to go when we die, and how something as accessible as a cur...

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Arthur Brooks is a Harvard professor, social scientist, and three-time New York Times bestselling author whose life's work centers on a single, urgent question: what actually makes a human life feel meaningful? In this conversation, we explore why depression and anxiety have surged since 2008, how technology has hijacked the part of the brain responsible for wonder and meaning, and what it looks like to live, as Arthur puts it, lik...

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Dr. Paul Conti is a psychiatrist, trauma specialist, and author whose work centers on one deceptively simple idea: that understanding yourself is the most powerful thing you can do for your mental health. In this conversation, we explore how the unconscious mind quietly sets the boundaries for how we think, feel, and move through life, and how much of what we assume is just "who we are" was actually formed long before we had the wo...

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Emily McDonald holds two degrees in neuroscience and has become one of the fastest-growing science communicators on social media. In this conversation, we explore how the brain constructs reality from the inside out — not as a passive receiver of the world, but as a constant prediction machine shaped by memory, belief, emotion, and past experience. From color vision to the kitten experiment, Emily brings the science to life i...

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Dr. Roman Yampolskiy joins me to explore one of the most urgent and uncomfortable questions of our time: what happens when we create intelligence that surpasses our own? We unpack the difference between the AI tools we use today and the emergence of artificial general intelligence, and why the transition from narrow systems to self-improving intelligence may mark a point where human control is no longer possible. Roman shares why e...

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Joe Hudson returns to explore a deeper layer of the inner work, and why peace alone is not the full picture of being human. We unpack the distinction between awakening in the mind and awakening in the heart, and how many people use meditation and awareness as a way to find calm, while still avoiding the emotional depth that brings real connection, intimacy, and joy. Joe shares how positive emotions can actually feel more threatenin...

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Wim Hof joins me to explore the deeper story behind his work, from profound personal loss to discovering a direct path back into the body through breath and cold exposure. We unpack how modern life pulls us out of feeling and into constant mental noise, and how reconnecting with the breath can bring us back into a state of presence, strength, and clarity. Wim shares how a single moment stepping into freezing water at 17 opened some...

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Emad Mostaque joins me to explore one of the most confronting questions of our time: what happens when human intelligence is no longer economically valuable? We unpack how rapidly advancing AI is moving toward a world where cognitive labor becomes obsolete, and why this shift may happen much sooner than most people expect. Emad shares how we’ve already built systems that can replicate human thinking, decision-making, and crea...

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Shi Heng Yi joins me to explore the path of self-mastery through the lens of the Shaolin tradition, and why, despite having more comfort and convenience than ever before, so many people still feel a deep sense of inner lack. We unpack the idea that external success, wealth, and achievement cannot replace a missing sense of inner stability, and how the constant search outside of ourselves often leads us further away from what we are...

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Dr. Nicole LePera joins me to explore how our childhood experiences shape the nervous system, emotional patterns, and identities we carry into adulthood. We unpack how many of the reactions, habits, and relationship dynamics that feel automatic today were once adaptations we developed to maintain connection and safety early in life. Nicole explains how emotional attunement in childhood forms the internal “home base” we ...

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Zen teacher and author Henry Shukman offers a clear and grounded introduction to the heart of Zen practice. We explore how awakening is not an escape from life, but a deeper participation in it — a realization that dissolves the illusion of separation and reveals a boundless field of awareness and love.

Henry shares his own spontaneous awakening experience at 19, the profound insight that life is not divided between self and w...

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Dr. Sue Morter returns to explore what it truly means to awaken — not as a concept, but as a lived, embodied experience. Beneath our protective personality and performance-driven identity lies a deeper intelligence — an electromagnetic master system that governs healing, perception, and consciousness itself.

In this conversation, we explore how nervous system regulation opens the doorway to higher awareness, why triggers...

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Nir Eyal joins the podcast to explore one of the most foundational forces shaping our lives: belief. What if the way you see reality isn’t reality itself, but a simulation filtered through prior assumptions, expectations, and unconscious scripts?

In this conversation, we unpack the difference between fact, faith, and belief—and why most of our suffering stems from confusing the three. Nir shares powerful research on pred...

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Swami Sarvapriyananda unpacks the philosophy of Advaita Vedanta and its central claim: you are not the body, not the mind, not even your thoughts — you are pure consciousness itself. Through rigorous reasoning rather than blind belief, he guides us step by step into a direct inquiry of who we truly are.

We explore the limits of faith-based religion, the pitfalls of mystical experience, the distinction between intelligence and ...

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Joscha Bach explores the nature of consciousness, free will, and reality through the lens of computation, cognitive science, and philosophy. Rather than treating the mind as a mystical entity, Joscha frames consciousness as a constructed dream—a model generated by the brain to make sense of the world and coordinate behavior.

We examine why beliefs should remain provisional, how the self functions as a useful fiction, and why s...

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In this conversation, David Ghiyam shares the spiritual framework that has guided his life for over 25 years—one rooted in the idea that reality operates according to universal spiritual laws, just as it does physical ones. Drawing from Kabbalistic wisdom and lived experience, David explains how the soul’s purpose is not comfort, but transformation, and how life’s challenges are designed to reconnect us with a dee...

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