Iedereen drinkt het, maar bijna niemand weet: hoeveel koppen koffie zijn nog gezond?
Tom test het op de harde manier, van een overdosis aan koffie naar cold turkey helemaal geen koffie en dokter Alexander legt uit wat de wetenschap zegt over de ideale dosis.
In deze aflevering bespreken ze:
- Helpt koffie écht tegen vermoeidheid?
- Hoeveel koppen koffie zijn goed voor je, en waarom is de timing belangrijk?
- Is koffie goed voor afvallen en je hartgezondheid?
- Droogt het je uit, en klopt het dat het je stresshormoon omhoog jaagt?
Tom test het in de praktijk, Alexander checkt de wetenschap.
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Onderzoeken die Alexander heeft gebruik voor deze aflevering:
- Blanchard J, Sawers SJ. The absolute bioavailability of caffeine in man. Eur J Clin Pharmacol. 1983;24(1):93-98. doi:10.1007/bf00613933
- Huang ZL, Qu WM, Eguchi N, et al. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci. 2005;8(7):858-859. doi:10.1038/nn1491
- Reichert CF, Deboer T, Landolt HP. Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives. J Sleep Res. 2022;31(4):e13597. doi:10.1111/jsr.13597
- Alasmari F. Caffeine induces neurobehavioral effects through modulating neurotransmitters. Saudi Pharm J. 2020;28(4):445-451. doi:10.1016/j.jsps.2020.02.005
- Tian DD, Natesan S, White JR , Jr, Paine MF. Effects of common CYP1A2 genotypes and other key factors on intraindividual variation in the caffeine metabolic ratio: An exploratory analysis. Clin Transl Sci. 2019;12(1):39-46. doi:10.1111/cts.12598
- Faber MS, Jetter A, Fuhr U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. doi:10.1111/j.1742-7843.2005.pto_973160.x
- Low JJL, Tan BJW, Yi LX, Zhou ZD, Tan EK. Genetic susceptibility to caffeine intake and metabolism: a systematic review. J Transl Med. 2024;22(1):961. doi:10.1186/s12967-024-05737-z
- Matthaei J, Tzvetkov MV, Strube J, et al. Heritability of caffeine metabolism: Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2. Clin Pharmacol Ther. 2016;100(6):606-616. doi:10.1002/cpt.444
- Parsons WD, Neims AH. Effect of smoking on caffeine clearance. Clin Pharmacol Ther. 1978;24(1):40-45. doi:10.1002/cpt197824140
- Gunes A, Ozbey G, Vural EH, et al. Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. Pharmacogenomics. 2009;10(5):769-778. doi:10.2217/pgs.09.22
- Kall MA, Clausen J. Dietary effect on mixed function P450 1A2 activity assayed by estimation of caffeine metabolism in man. Hum Exp Toxicol. 1995;14(10):801-807. doi:10.1177/096032719501401004
- Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis. 1992;13(9):1561-1568. doi:10.1093/carcin/13.9.1561
- Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol. 1985;28(4):425-428. doi:10.1007/bf00544361
- Gunes A, Dahl ML. Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics. 2008;9(5):625-637. doi:10.2217/14622416.9.5.625
- Lane JD, Steege JF, Rupp SL, Kuhn CM. Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol. 1992;43(5):543-546. doi:10.1007/bf02285099
- Tracy TS, Venkataramanan R, Glover DD, Caritis SN, National Institute for Child Health and Human Development Network of Maternal-Fetal-Medicine Units. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. Am J Obstet Gynecol. 2005;192(2):633-639. doi:10.1016/j.ajog.2004.08.030
- Djordjevic N, Ghotbi R, Bertilsson L, Jankovic S, Aklillu E. Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes. Eur J Clin
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