Onze darmen worden vaak het tweede brein genoemd, maar klopt dat eigenlijk? Deze week duiken Tom en Alexander diep in de wereld van het microbioom. Tom testte een week lang probiotica: voel je je dan echt lichter, energieker, minder… gasachtig? Alexander legt uit waarom rauwe zuivel zo’n hype is én hoe een poeptransplantatie iemands leven kan redden. 💩🥛
In deze aflevering:
💊 Neem probiotica en geen antibiotica
🧠 Je darmen zijn je tweede brein
⚖️ Je microbioom bepaalt hoe dik en hoe ziek je wordt
🚑 Poeptransplantaties redden levens
Tom stelt de vragen, Alexander fileert de feiten. Zodat jij voortaan weet: wat helpt je darmen écht, wat is dure onzin, en wanneer je beter niet blind een potje ‘probiotica power’ hoeft te kopen.
Onderzoeken uit deze aflevering:
- McDonnell L, Gilkes A, Ashworth M, Rowland V, Harries TH, Armstrong D, White P. Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis. Gut Microbes. 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2020.1870402. PMID: 33651651; PMCID: PMC7928022.
- de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022 May;71(5):1020-1032. doi: 10.1136/gutjnl-2021-326789. Epub 2022 Feb 1. PMID: 35105664; PMCID: PMC8995832.
- Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek. 2020 Dec;113(12):2019-2040. doi: 10.1007/s10482-020-01474-7. Epub 2020 Nov 2. PMID: 33136284.
- Lee J-Y, Bays DJ, Savage HP, Bäumler AJ. The human gut microbiome in health and disease: time for a new chapter? Infect Immun. 2024 Nov 12;92(11):e0030224. doi: 10.1128/iai.00302-24. Epub 2024 Sep 30. PMID: 39347570; PMCID: PMC11556149.
- Mayer EA, Nance K, Chen S. The Gut-Brain Axis. Annu Rev Med. 2022 Jan 27;73:439-453. doi: 10.1146/annurev-med-042320-014032. Epub 2021 Oct 20. PMID: 34669431.
- Petrut SM, Bragaru AM, Munteanu AE, Moldovan AD, Moldovan CA, Rusu E. Gut over Mind: Exploring the Powerful Gut-Brain Axis. Nutrients. 2025 Feb 28;17(5):842. doi: 10.3390/nu17050842. PMID: 40077713; PMCID: PMC11901622.
- Margolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology. 2021 Apr;160(5):1486-1501. doi: 10.1053/j.gastro.2020.10.066. Epub 2021 Jan 22. PMID: 33493503; PMCID: PMC8634751.
- Gupta K, Tappiti M, Nazir AM, Koganti B, Memon MS, Aslam Zahid MB, Shantha Kumar V, Mostafa JA. Fecal Microbiota Transplant in Recurrent Clostridium Difficile Infections: A Systematic Review. Cureus. 2022 May 5;14(5):e24754. doi: 10.7759/cureus.24754. PMID: 35693372; PMCID: PMC9174020.
- Porcari S, Baunwall SMD, Occhionero AS, Ingrosso MR, Ford AC, Hvas CL, Gasbarrini A, Cammarota G, Ianiro G. Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: A systematic review and meta-analysis. J Autoimmun. 2023 Dec;141:103036. doi: 10.1016/j.jaut.2023.103036. Epub 2023 Apr 23. PMID: 37098448.
- Lerner A, Shoenfeld Y, Matthias T. Probiotics: If It Does Not Help It Does Not Do Any Harm. Really? Microorganisms. 2019 Apr 11;7(4):104. doi: 10.3390/microorganisms7040104. PMID: 30979072; PMCID: PMC6517882.
- Nel Van Zyl K, Matukane SR, Hamman BL, Whitelaw AC, Newton-Foot M. Effect of antibiotics on the human microbiome: a systematic review. Int J Antimicrob Agents. 2022 Feb;59(2):106502. doi:
- Lerner A, Shoenfeld Y, Matthias T. Probiotics: If It Does Not Help It Does Not Do Any Harm. Really? Microorganisms. 2019 Apr 11;7(4):104. doi: 10.3390/microorganisms7040104. PMID: 30979072; PMCID: PMC6517882.
- Pomares Bascuñana RÁ, Veses V, Sheth CC. Effectiveness of fecal microbiota transplant for the treatment of Clostridioides difficile diarrhea: a systematic review and meta-analysis. Lett Appl Microbiol. 2021 Aug;73(2):149-158. doi: 10.1111/lam.13486. Epub 2021 May 8. PMID: 33864273.
- Eliaz I. The Failure of Probiotics-and the Strategy of Microbiome Synergy. Integr Med (Encinitas). 2020 Jun;19(3):8-10. PMID: 33132772; PMCID: PMC7572142.
- Chandrasekaran P, Weiskirchen S, Weiskirchen R. Effects of Probiotics on Gut Microbiota: An Overview. Int J Mol Sci. 2024 May 30;25(11):6022. doi: 10.3390/ijms25116022. PMID: 38892208; PMCID: PMC11172883.10.1016/j.ijantimicag.2021.106502. Epub 2021 Dec 18. PMID: 34929293.
- Ramirez J, Guarner F, Bustos Fernandez L, Maruy A, Sdepanian VL, Cohen H. Antibiotics as Major Disruptors of Gut Microbiota. Front Cell Infect Microbiol. 2020 Nov 24;10:572912. doi: 10.3389/fcimb.2020.572912. PMID: 33330122; PMCID:
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
The Joe Rogan Experience
The official podcast of comedian Joe Rogan.
On Purpose with Jay Shetty
I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!