ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

Space travel, electric vehicles, future-powering batteries—the ability to push technology forward and to bring it into the world in a real way is without a doubt the best of Elon Musk. In his 600 page biography, Walter Isaacson chronicles a man with superlative engineering skills, but who “doesn’t have a fingertip feel for social emotional networks.” On this first of four episodes, Isaacson shares the aspects of Musk that gave mean...

What kind of titan of industry has a "giddy mode"? Or a "demon mode"? The two aspects of Musk’s personality are forces that drive his choices and behavior at work—and vectors Isaacson finds critical to understanding how Musk operates. From ripping out servers on Christmas Eve on a whim to buying Twitter against better wisdom, and reaming out staff members left right and center, we stare into the darker parts of Musk as chronicled b...

Be a storyteller, not a preacher. That was novelist Walker Percy’s legendary advice to a young Walter Isaacson. One he takes to heart in his work as a journalist at Time and CNN, and as a biographer of creative genius across the centuries—and in trying to capture someone as volatile as Elon Musk. He reflects on the challenges of holding the complexity of a character in his mind—and the minds of readers—in the modern age, when every...

From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Shell Games, Longform) comes a revealing look into the life of Ben Franklin, and how his genius shaped America. 

In this first episode of five, we dive into the way Franklin's scientific curiosity laid the groundwork for his approach to democracy, and how his thirst for innovation not only led him to invent everything...

Few people remember that Benjamin Franklin was America’s wealthiest self-made man. After being denied a formal education and then indentured to his own brother, he launched America's first media empire. But while Franklin could be a ruthless businessman, he was out for more than himself—he knew his success was predicated on a strong middle class, a new, American idea. So he started civic ventures like fire departments, street sweep...

After retiring at the age of 42, Ben Franklin immersed himself in politics, taking on enormous diplomatic challenges on behalf of Pennsylvania and the colonies. In this episode, we dive into Franklin the talented statesman-- a man who emerged from his mission in England with a taste for revenge, charmed the French into supporting a burgeoning nation, and somehow found time to get involved in every revolutionary tract-- from Common ...

In this final episode of our series, host Evan Ratliff and biographer Walter Isaacson discuss Benjamin Franklin's remarkable late-in-life achievements-- from his last anonymous essay, to the way he empowered George Washington, to his evolution on slavery, to the beautiful way Philadelphia mourned its favorite son... oh, and they discuss Ben Franklin's favorite magic trick, too! 

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Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. 

Evan sits down with Walter Isaacson to understand how Doudna’s upbring...

Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Their curiosity would prove to be the foundation for a history altering disco...

Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. 

Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work f...

As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity. 

Walter Isaacson sits down with Evan and tells him why the field has always been r...

In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doud...