ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson
A single scientific breakthrough changed the future of humanity, setting off the third great revolution of modern times. As with any revolution, things didn’t happen neatly or quietly. One figure stood at the center of it all: Jennifer Doudna, the Nobel Prize-winning biochemist who co-created CRISPR. Her invention signified the arrival of a newfound ability to edit our genes, as simply as we edit a sentence, with a word processor. From Walter Isaacson - the bestselling biographer behind Musk, Einstein and Steve Jobs – and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Jennifer Doudna. Her personal trajectory, and that of her collaborators and competitors, tells the story of how we arrived at this new frontier of gene editing. It’s a story filled with global stakes and fiery competition. And a story that touches upon the ethical considerations that gene editing brings. Season 2: He didn’t have a role in Hamilton, but America wouldn’t be the same without him! From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Ben Franklin, and how his genius shaped our national character. From Franklin’s adventures as a mischievous apprentice, to his evolution over 84 years into America’s best writer, inventor,scientist, diplomat, and business strategist… as well as Founding Father, Isaacson covers everything from the wit behind Poor Richard’s Almanac to the wisdom behind the Declaration of Independence; not to mention, how a former slave owner evolved into the shepherd of a near-perfect Constitution. In this intimate behind the scenes interview, Isaacson provides a look at how he came to understand Franklin’s remarkable life, how it shaped America’s national identity, and why Ben Franklin matters so much right now. Season 1: What is it like to shadow Elon Musk for two years? To sit courtside as he builds a rocket? Or tears apart an engineer? Or couch surfs at the homes of billionaires? And how on earth do you make sense of it all? Walter Isaacson is the biographer of giants: DaVinci, Franklin, Doudna, Jobs...and now Musk, former enfant terrible, rocket launcher, electric car innovator, and Twitter—er, X—disruptor, to put it gently. In this four-part series, author Evan Ratliff (“Mastermind,” “Longform” Podcast) sits down with Isaacson to draw out the behind-the-scenes stories of this epic biography, and what the writer has learned as an outsider inside Silicon Valley.
Episodes
Space travel, electric vehicles, future-powering batteries—the ability to push technology forward and to bring it into the world in a real way is without a doubt the best of Elon Musk. In his 600 page biography, Walter Isaacson chronicles a man with superlative engineering skills, but who “doesn’t have a fingertip feel for social emotional networks.” On this first of four episodes, Isaacson shares the aspects of Musk that gave mean...
What kind of titan of industry has a "giddy mode"? Or a "demon mode"? The two aspects of Musk’s personality are forces that drive his choices and behavior at work—and vectors Isaacson finds critical to understanding how Musk operates. From ripping out servers on Christmas Eve on a whim to buying Twitter against better wisdom, and reaming out staff members left right and center, we stare into the darker parts of Musk as chronicled b...
Be a storyteller, not a preacher. That was novelist Walker Percy’s legendary advice to a young Walter Isaacson. One he takes to heart in his work as a journalist at Time and CNN, and as a biographer of creative genius across the centuries—and in trying to capture someone as volatile as Elon Musk. He reflects on the challenges of holding the complexity of a character in his mind—and the minds of readers—in the modern age, when every...
Which of Musk’s efforts will mark his legacy? Will it be Starship and his work bringing Americans back into orbit, or will it be X and his amplifications of the worst of humanity? Isaacson wrestles with his time in Silicon Valley, and relays a comparison of Jobs and Musk that’s sure to stay with you.
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Introducing ON Benjamin Franklin with Walter Isaacson - an intimate behind the scenes interview to understand Benjamin Franklin’s remarkable life.
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From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Shell Games, Longform) comes a revealing look into the life of Ben Franklin, and how his genius shaped America.
In this first episode of five, we dive into the way Franklin's scientific curiosity laid the groundwork for his approach to democracy, and how his thirst for innovation not only led him to invent everything...
From writing under pen names in the newspaper as a teenager, to the Poor Richard maxims we all know, to the autobiography he created to show the path toward American virtues, Ben Franklin literally wrote the books on what it means to be American. But how close was the real Ben Franklin to the character he created?
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Few people remember that Benjamin Franklin was America’s wealthiest self-made man. After being denied a formal education and then indentured to his own brother, he launched America's first media empire. But while Franklin could be a ruthless businessman, he was out for more than himself—he knew his success was predicated on a strong middle class, a new, American idea. So he started civic ventures like fire departments, street sweep...
After retiring at the age of 42, Ben Franklin immersed himself in politics, taking on enormous diplomatic challenges on behalf of Pennsylvania and the colonies. In this episode, we dive into Franklin the talented statesman-- a man who emerged from his mission in England with a taste for revenge, charmed the French into supporting a burgeoning nation, and somehow found time to get involved in every revolutionary tract-- from Common ...
In this final episode of our series, host Evan Ratliff and biographer Walter Isaacson discuss Benjamin Franklin's remarkable late-in-life achievements-- from his last anonymous essay, to the way he empowered George Washington, to his evolution on slavery, to the beautiful way Philadelphia mourned its favorite son... oh, and they discuss Ben Franklin's favorite magic trick, too!
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Walter Isaacson - bestselling biographer behind Musk, Einstein and Steve Jobs - in conversation with Evan Ratliff brings you behind the scenes of The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. The story of the third great technological revolution in modern times.
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Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna.
Evan sits down with Walter Isaacson to understand how Doudna’s upbring...
Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Their curiosity would prove to be the foundation for a history altering disco...
Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer.
Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work f...
As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity.
Walter Isaacson sits down with Evan and tells him why the field has always been r...
In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doud...
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