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October 15, 2025 36 mins

What does it take to build a Biotech from scratch - with no data, no academic spinout, and nothing but two founders and two laptops?

In this episode of Careers in Discovery, we’re joined by Federico Paoletti, CEO & Co-founder of Exogene, to find out.

Federico shares the story of how he went from a PhD in cancer biology to co-founding an Oxford-based immuno-oncology Biotech, working at the intersection of AI and protein engineering to develop personalised T-cell engager therapies. He talks about why he left academia despite loving science, what “high agency” really means in a Biotech startup, how to win partnerships, funding, and talent with no track record, and how curiosity - and trust - shaped Exogene’s culture from the very beginning.

If you're thinking about the leap into Biotech entrepreneurship, or flexing your leadership muscle in a startup setting, Federico’s journey will inspire you to go after the bold ideas - and find the people who will build them with you.

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