Keywords
Chronic cough, TRP receptors, P2X3 receptors, neuroplasticity, allergy, immunology, ATP release, bronchial epithelial cells, therapeutic approaches, research
Summary:
In this episode of the Clinical and Experimental Allergy podcast, Dr. Jonathan Bernstein discusses his research on chronic cough, focusing on the role of TRP receptors and P2X3 receptors in understanding the mechanisms behind this condition. He shares insights from his in vitro studies, unexpected findings related to chronic cough pathways, and potential future therapeutic approaches targeting these receptors.
Takeaways
- Dr. Bernstein is a professor of medicine at the University of Cincinnati.
- His research focuses on chronic cough and its underlying mechanisms.
- In vitro assays help isolate different cell activation pathways.
- ATP release is critical for activating P2X3 receptors on bronchial epithelial cells.
- Unexpected pathways activated by ATP include FAC signaling and IL-4.
- P2X3 antagonists can down-regulate pathways promoting airway inflammation.
- TRP receptors are the first interface between the body and the environment.
- Nonspecific triggers can activate TRP receptors, leading to increased ATP release.
- Selective antagonists for TRP receptors are still lacking.
- The nervous system plays a critical role in cough reflex mechanisms.
Popular Podcasts
Las Culturistas with Matt Rogers and Bowen Yang
Ding dong! Join your culture consultants, Matt Rogers and Bowen Yang, on an unforgettable journey into the beating heart of CULTURE. Alongside sizzling special guests, they GET INTO the hottest pop-culture moments of the day and the formative cultural experiences that turned them into Culturistas. Produced by the Big Money Players Network and iHeartRadio.
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.