Dr. Gabrielle Hutchison Donaldson dives into the 2025 Nobel Prize in Physiology or Medicine for discoveries about regulatory T cells (T‑regs), explaining why these immune brakes matter and how they control self‑tolerance.
The episode links T‑reg biology to diabetes and diabetic foot ulcers, covering mechanisms, early T‑reg therapies, and how boosting regulatory pathways could reduce chronic inflammation and improve wound healing.
Practical takeaways include maintaining tight glycemic control, following standard wound care, considering clinical trials, and watching for future localized or engineered T‑reg strategies that might speed healing and prevent amputations.
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