This Episode is based on a comprehensive review article on therapeutic antiaging strategies (presented by MDPI, Basel, Switzerland). It explores aging as a progressive physiological process characterized by nine specific hallmarks, which are significant risk factors for various diseases. The review discusses different antiaging approaches based on these hallmarks, drawing on in vitro and in vivo research experiments. Strategies covered include anti-inflammatory drugs, antioxidant activity, telomere reactivation, epigenetic drugs, activation of the proteolytic system, mitophagy activators, inhibition of mTOR and insulin/IGF-1 signaling, activation of AMPK and Sirtuin signaling, clearance of senescent cells, stem cell-based therapies, the role of the microbiome, and noncoding RNAs. Ultimately, the article aims to highlight methods for promoting healthy aging and potentially extending human lifespan.
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