“If we truly want to focus on preventative medicine and address the biggest risk factor, that risk factor is the biological aging process,” says Ryan Smith, the co-founder of TruDiagnostic, a company at the forefront of epigenetic testing. In this episode, he joins Dr. Regina Druz to break down how advanced tools like DNA methylation clocks are redefining what we know about aging and health.
Is your body aging at the same rate as your chronological years? Ryan explains why that might not be the case and how TruDiagnostic’s DNA methylation technology offers a clearer picture of your biological health. These tools look into how different organ systems age, and provide actionable insights that can shape personalized health interventions.
Dr. Druz and Ryan discuss the evolution of epigenetic clocks, from Steve Horvath’s huge breakthrough to today’s advanced tools like DunedinPACE and SYMPHONYAge. They go into why these clocks are more effective than traditional biomarkers like telomere length and how they can measure the impact of lifestyle changes in real-time.
This episode challenges how we think about aging. If biological age is a stronger predictor of health outcomes, what does that mean for the way we approach preventative care? Join Dr. Druz and Ryan’s discussion to gain a clear understanding of how science is shaping the future of longevity and health optimization.
Quotes
- “I just want to stress the importance of this process of aging. I think when people hear about it, they might think of things like aesthetics, their skin appearance, or some of these more vain applications. But what most people don’t realize is that aging is the biggest risk factor for almost every chronic disease and death.” (04:42 | Ryan Smith)
- “By looking at an individual’s longitudinal journey, we can get clearer signals of what happens as we age. The DunedinPACE gives you a pace of aging, showing how fast you’re aging right now. It’s helpful because it’s responsive to short-term interventions and strongly correlated to quality of life. Some may think about their grandparents’ later years and worry about quality of life, but healthspan and lifespan are correlated—improving one often improves the other. These clocks help us optimize both.” (21:50 | Ryan Smith)
- “This opened a new chapter in how I approach patients at the Holistic Heart Centers, where we optimize metabolic health using digital biomarkers like stress patterns, sleep patterns, body composition, heart rate, blood pressure curves, and metabolic health parameters. We can now see how personalized interventions impact longevity.” (40:21 | Dr. Regina Druz)
Links
Schedule a Discovery Call: https://go.holisticheartcenters.com/apply
Access Courses and Events: https://holisticheartcenters.info/hearthealth
Get Heartwell Toolkits: https://shop.holisticheartcenters.com/
Schedule a Business Meeting:https://calendly.com/heartcenters
Connect with Dr. Regina Druz:
Website: http://holisticheartcenters.com
YouTube: https://www.youtube.com/@reginadruzmd
Instagram: https://www.instagram.com/dr.reginadruz
Facebook: https://www.facebook.com/holisticheartcenters
Twitter: https://x.com/heartCenters
Popular Podcasts
On Purpose with Jay Shetty
I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
Ridiculous History
History is beautiful, brutal and, often, ridiculous. Join Ben Bowlin and Noel Brown as they dive into some of the weirdest stories from across the span of human civilization in Ridiculous History, a podcast by iHeartRadio.