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August 21, 2025 61 mins

Lipoprotein(a) might be one of the most important pieces of the heart health puzzle that most people have never heard about.

 

Dr. Regina Druz sits down with cardiologist and lipidology expert Dr. Guy Mintz to discuss why this particle deserves far more attention in cardiology. Lipoprotein(a) is often left out of standard cholesterol tests, yet it is linked to early heart attacks, strokes, valve disease, and aggressive atherosclerosis. If lowering cholesterol only cuts cardiovascular risk in half, what explains the rest? Could Lipoprotein(a) be the missing factor that shapes a person’s long-term health?

 

The conversation looks closely at the science behind Lipoprotein(a), its genetic roots, and why doctors call it a “genetic tattoo.” You’ll hear why every adult should ask for this test, why family members of those with elevated levels need screening, and how new drugs in development may soon lower Lipoprotein (a) by up to 90%. Until then, heart attack prevention depends on various steps like lifestyle choices, aggressive cholesterol control, and in some cases, apheresis.

 

This episode encourages a broader view of heart health, one that goes beyond LDL cholesterol to include genetics, inflammation, and personalized care. What would change if you knew your Lipoprotein(a) level? How would that knowledge shape the way you approach prevention?

 

Episode Breakdown:

00:00 Lipoprotein(a) and the Future of Heart Health

04:49 Why Lipoprotein(a) Raises Heart Attack and Stroke Risk

14:13 Genetics of Lipoprotein(a) and Family Screening

27:18 Should Lipoprotein(a) Be in Standard Cholesterol Tests

35:12 New Therapies to Lower Lipoprotein(a)

52:29 Residual Risk and Heart Attack Prevention

 

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Connect with Dr. Regina Druz:

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Podcast production and show notes provided by HiveCast.fm

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