Your genetics might be the key to lasting weight loss. Dr. Phyllis Pobee knows firsthand how frustrating it can be to do everything “right” and still struggle with weight. In this episode, Dr. Pobee joins Dr. Regina Druz to discuss how genetics for weight loss plays a bigger role than most people realize. Could your genes for weight loss be working against you? And if so, what can you do about it?
From nutritional genetics to hormones like cortisol and estrogen, Dr. Pobee breaks down why weight gain—especially for women over 30—isn’t just about diet and exercise. She shares how understanding your genetic profile can help you make smarter choices about food, exercise, and stress management. They also dig into the rise of weight loss medications like Ozempic and whether they truly solve the problem or just mask deeper imbalances.
This episode challenges the idea that weight loss is simply about willpower. If you’ve ever felt stuck, Dr. Druz and Dr. Pobee’s conversation might be exactly what you need to move forward with a strategy that actually works for your body.
Episode Breakdown:
00:00 Introduction
03:57 Hormonal Interplay in Weight Management
05:11 Estrogen and Heart Disease in Women
07:07 Genetic Variations and Hormonal Imbalances
08:41 Cortisol and Stress Management
10:21 Circadian Rhythm and Eating Habits
12:15 Measuring Cortisol Levels
17:54 Effective Stress Management Techniques
20:47 Testing Cortisol Levels
26:00 Hormonal Changes in Perimenopause and Menopause
30:56 Estrogen Dominance and Genetic Influence
34:00 Caution with Hormone Replacement Therapy
37:18 Key Genetic Variations Women Should Know
42:19 Overstressing and Its Impact on Weight Loss
45:25 Integrative Approach to Weight Loss
49:37 Polygenic Risk Scores in Clinical Applications
Links
Schedule a Discovery Call: https://go.holisticheartcenters.com/apply
Access Courses and Events: https://holisticheartcenters.info/hearthealth
Get Heartwell Toolkits: https://shop.holisticheartcenters.com/
Schedule a Business Meeting:https://calendly.com/heartcenters
Connect with Dr. Regina Druz:
Website: http://holisticheartcenters.com
YouTube: https://www.youtube.com/@reginadruzmd
Instagram: https://www.instagram.com/dr.reginadruz
Facebook: https://www.facebook.com/holisticheartcenters
Twitter: https://x.com/heartCenters
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