In this eye‑opening episode, we unpack the topic “Why Your Antidepressant Might Not Be Enough: Understanding Treatment‑Resistant Depression.” We explore what it means when conventional medications don’t deliver the hoped-for relief—and why that’s more common than many realize.
Episode Highlights:
What exactly is treatment‑resistant depression (TRD)? We break down its definition—typically when two or more antidepressants fail to significantly reduce symptoms.
How widespread is TRD? Nearly 30% of individuals with major depressive disorder may meet the criteria.
Root causes behind inadequate treatment response—including misdiagnosis, discontinuation of therapy, underlying medical conditions, and more.
What comes next? We discuss innovative alternatives like repetitive transcranial magnetic stimulation (rTMS), electroconvulsive therapy (ECT), medication augmentation strategies, esketamine nasal spray, and emerging experimental options.
Why Listen?
Whether you're a healthcare professional, someone navigating depression treatment, or simply curious about mental health breakthroughs—this episode sheds light on why a single medication may not suffice and what other evidence-based treatments are reshaping care.
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