Female Senescence: Longevity and Morbidity

The provided text examines the "male-female health-survival paradox," where women generally live longer but experience more chronic illnesses and disability in later life. It proposes that cellular senescence, a state where damaged cells stop dividing but remain active and secrete inflammatory molecules (SASP), is a key mechanism behind this phenomenon. The report attributes the paradox in females to three main pillars: their unique genetic makeup involving the second X chromosome, the dynamic influence of estrogen throughout their lives, and their distinctly reactive immune system. Furthermore, the text explores how this biological interplay contributes to common female late-life conditions like osteoporosis, frailty, autoimmune diseases, and neurodegenerative disorders, ultimately suggesting that future therapeutic strategies targeting senescence must consider these sex-specific differences for optimal efficacy and safety.

Research done with the help of artificial intelligence, and presented by two AI-generated hosts.