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June 17, 2025 61 mins
Un nouvel épisode du Pharmascope, à saveur pédiatrique, est disponible! Dans ce 158e épisode, Nicolas, Isabelle, Olivier et une illustre invitée discutent du RGO chez les tout-petits et les un peu plus vieux.  Les objectifs pour cet épisode sont les suivants: Expliquer les manifestations cliniques et la prise en charge du RGO en pédiatrie. Discuter de l’approche non-pharmacologique du RGO en pédiatrie. Comparer les données d’efficacité et d’innocuité des différents médicaments utilisés dans le traitement du RGO en pédiatrie. Ressources pertinentes en lien avec l’épisode  Rosen R, et coll. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):516-554. Chevalier I, Beck CE, Doré-Bergeron MJ, Orkin J; Société canadienne de pédiatrie. La prise en charge médicale du reflux gastro-œsophagien chez les nourrissons en santé. Nov 2022. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics. 2008 Dec;122(6):e1268-77. Kwok TC, Ojha S, Dorling J. Feed thickener for infants up to six months of age with gastro-oesophageal reflux. Cochrane Database Syst Rev. 2017 Dec 5;12(12):CD003211. Tighe MP, Andrews E, Liddicoat I, Afzal NA, Hayen A, Beattie RM. Pharmacological treatment of gastro-oesophageal reflux in children. Cochrane Database Syst Rev. 2023 Aug 22;8(8):CD008550. Fernández-González SM, Moreno-Álvarez A, Solar-Boga A. Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomized Controlled Trials. Children (Basel). 2024 Mar 1;11(3):296. Terrin G, et coll. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics. 2012 Jan;129(1):e40-5. Canani RB, et coll; Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP). Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics. 2006 May;117(5):e817-20. Lassalle M, Zureik M, Dray-Spira R. Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children. JAMA Pediatr. 2023 Oct 1;177(10):1028-1038. Wang YH, Wintzell V, Ludvigsson JF, Svanström H, Pasternak B. Association Between Proton Pump Inhibitor Use and Risk of Fracture in Children. JAMA Pediatr. 2020 Jun 1;174(6):543-551.
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