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April 21, 2025 14 mins

For years, people have cautioned we wait to do anything about AI until it starts demonstrating “dangerous capabilities.” Those capabilities may be arriving now.

Virology knowledge has been limited to a small number of experts. Expertise in dual-use fields like virology is difficult to attain, with people completing multiple degrees and dedicating their careers to reaching the forefront of research. Where knowledge is publicly available, the jargon-heavy literature is largely indecipherable to most people outside the field. To perform research involving biosafety level 3 (BSL-3) pathogens—such as SARS, anthrax, or H5N1 influenza—researchers must clear a series of approvals, including facility certification, security clearances, specialized training, and ongoing medical surveillance. Only then can they get access to these pathogens and begin acquiring the tacit skills needed to work with them

These high barriers to entry have limited the pool of people with access to powerful dual-use knowledge, keeping the chances [...]

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Outline:

(07:19) Friction as a key factor

(10:47) A ticking time bomb

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First published:
April 22nd, 2025

Source:
https://aifrontiersmedia.substack.com/p/ais-are-disseminating-expert-level

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Narrated by TYPE III AUDIO.

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Images from the article:

VCT question showing plaque assay troubleshooting with purple-stained cell culture plate.

The image shows a scientific question about troubleshooting a plaque assay for influenza virus, accompanied by a photograph of a circular cell culture plate stained uniformly in purple. The plate appears to lack distinct plaques or clear zones that would typically indicate viral infection sites. Below the question are seven possible answer statements labeled A through G addressing potential causes of the assay issues.

The question concerns low contrast in the plaque assay, with specific experimental conditions detailed regarding MDCK cells, virus infection parameters, and overlay medium composition. The uniform purple staining makes quantification difficult, which is the core issue being addressed in this troubleshooting scenario.
Four bar graphs comparing accuracy across different models: VCT, ProtocolQA, Bio-LP, WMDP-Bio.

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