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December 19, 2025 39 mins

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In this episode of Brain Trash, Maria and Tabitha unpack how hormones hijack mental health, especially for people with ADHD navigating birth control, perimenopause, menopause, and hormone replacement therapy (HRT).

They explore how hormonal shifts affect dopamine, medication response, mood regulation, and executive function, why ADHD symptoms often worsen during hormonal transitions, and how testosterone, estrogen, and progesterone interact with psychiatric treatment.

The conversation also highlights gaps in women’s health research, the importance of individualized care, and why patients must advocate for themselves when treatment suddenly stops working.

If you’ve ever wondered why your meds feel different, your symptoms escalated out of nowhere, or no one warned you about menopause being a mental health event, this episode is for you.

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