Founders and Builders
Founders & Builders is your go-to channel for in-depth conversations with the world's best startup founders and operators. Whether you’re an aspiring founder, a seasoned entrepreneur, or simply curious about the journey of building your own business, you'll find real-world experiences, and candid advice from successful entrepreneurs who have been in the trenches. Join us as we explore the highs and lows of entrepreneurship, uncover the secrets to startup success, and dive into the future of technology and business. Subscribe to be inspired, informed, and equipped to build something great!
Episodes
In this clip, Pinstripe Chris reflects on creativity, discipline, and why life is ultimately about experiences and memories, not just work. He talks about the balance between Rick Rubin’s go-with-the-flow approach and Steven Pressfield’s disciplined mindset, and how both shape his outlook on art and life.👉 If you enjoyed this, check out the full episode for the complete conversation.
“I’ve never had a problem betting on me.” Chris Dunlop (Pinstripe Chris) Chris built a global brand painting one-off masterpieces for companies like Porsche without art school, safety nets, or a plan B.
🔍 What You’ll Learn In This Episode:
- Why the boldest investment you can make is in yourself.
- The hidden process behind Pinstripe Chris’s “overnight success.”
- How to build creative freedom instead of getting stuck chasing paycheck...
🚀 “Entire software categories are up for grabs.”
Investor Akash Bajwa explains why the next wave of AI‑native startups will rewrite today’s playbooks and how first‑time founders can ride it.
What you’ll learn
- The three‑layer stack (AI chips → models → apps) and the product & data flywheel that lets tiny startups punch above their weight.
- A clear framework for deciding “AI‑native or AI‑assist?” for your startup. Why 2025 fe...
💊 90% of drugs fail. Clinical trials take years. And billions are lost every time.
In this episode of Founders & Builders, I sit down with Dr. Olga Kubassova, a mathematician turned biotech investor, and founder of Image Analysis Group — a company using AI-powered imaging biomarkers to reinvent how we measure whether a drug is actually working.
We cover:
🧠 Why clinical trials are broken — and what needs to change
📉 How AI biomar...
🧬 Most new medicines are billion-dollar bets made in the dark.Charm Therapeutics is changing that — using AI to design drugs that actually work.Laksh Aithani, co-founder and CEO, joins the Founders and Builders podcast to break down how AI is transforming drug discovery — and why Charm raised $50M from Nvidia, General Catalyst, and Khosla Ventures to do it.We talk about:– The wild science behind protein folding– Why most drugs sti...
He built a product from $0 to $1B+ at Google.
Now he’s building the integration layer for the AI-first future of SaaS. In this episode of Founders & Builders, I sit down with Romain Sestier, CEO and co-founder of StackOne — the next-gen platform unlocking 3,000+ actions across 200+ SaaS tools for AI agents and enterprise software.
We dive into:
🧠 Why integrations are now table stakes for SaaS success
⚙️ How StackOne is reinventin...
What if banks weren’t built in the 1800s? What if we could start again?David Brear, CEO and founder of 11:FS joins Founders & Builders to unpack what it really means to build digital financial services from scratch—and why most of what exists today is just a “digital facade.”David shares: • The origin story of 11:FS and how they scaled globally • How he spots broken systems ripe for disruption • His lessons on building products...
Will, Co-Founder of Workflow shares with us his perspective on:Finding the right problems to solve, how to define your vision as a founder, placing the right bets when building your startup and more.Will previously founded Rota, the UK's fastest growing on-demand staffing platform.Follow Will on X/Twitter: x.com/willrftaylor
🎙 Sebastiaan Debrouwere — From VC to Founder: The Future of AI-Powered E-commerceIn this episode of Founders & Builders, we sit down with Sebastiaan Debrouwere, founder of Genie, the engine behind over 150 of Shopify’s fastest-growing brands.Seb shares a rare founder’s perspective shaped by both operating and investing — previously in Balderton Capital, the fund behind Revolut and Depop.We explore: • His unconventional take on...
Mahdi, Co-Founder of Humble AI shares with us his perspective on: Building AI startups, the importance of creating meaningful relationships, how to define your vision as a founder, the opportunity ahead in the AI revolution and more. Mahdi has also angel-invested in early-stage startups and funds, including Tiny.VC, Aire.io, Purple.AI, Pathao, Sheetgo, Silkfred, Noty.AI & JustPark. Timestamps: 00:00 - intro 10:50 - optimizing...
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