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February 5, 2025 26 mins

Dr. Jessica Pelletier and Noah Kronk speak with Dr. Stephen Liang, an emergency medicine physician and infectious disease expert, about the diagnosis and management of mpox in the ED setting.

Take-Home Points:

  • Two clades:
    • Clade 1 (Central Africa): classic, more severe disease
    • Clade 2 (West Africa): subtle, non-classic presentations including genital/anal lesions and proctitis in the 2022 global outbreak
  • Transmitted via exposure to body fluids, skin lesions, or respiratory secretions
  • Incubation period: 5-14 days
  • Lesions can mimic a wide range of diseases - keep a broad differential, including other sexually transmitted infections in the right context
  • For most patients, care is supportive
  • Those with or at high risk for severe disease should receive tecovirimat

You can view the full show notes and references here: https://docs.google.com/document/d/1CS5lo3HhvE_FiuDDgPPDkUnXHf49gydahGSWiGBlDFA/edit?usp=sharing

Episode art attribution: NIAID, CC BY 2.0 <https://creativecommons.org/licenses/by/2.0>, via Wikimedia Commons

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