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April 10, 2025 18 mins

Nephrotic syndrome is a kidney disorder that can cause severe swelling, protein loss, and an increased risk of clotting—but what exactly goes wrong in the body to trigger these symptoms? In this episode, Dr. Morgan Taylor, DNP, CPNP, CCRN, breaks down the pathophysiology of nephrotic syndrome, how it leads to massive fluid shifts, and the key nursing interventions that can improve patient outcomes. 

Learn how to recognize the hallmark signs of nephrotic syndrome, understand why the body’s response to protein loss makes things worse, and explore a real clinical case that highlights the importance of early recognition and treatment. Plus, Morgan walks through a test question to reinforce key takeaways for both the NCLEX and clinical practice. 

Topics discussed in this episode: 

• How glomerular damage leads to massive protein loss 

• Why proteinuria causes fluid overload, edema, and third-spacing 

• The liver’s response: Increased cholesterol and clotting risk 

• A real patient case of nephrotic syndrome caused by lupus and NSAID overuse 

• How steroids, diuretics, and albumin help manage nephrotic syndrome 

• The role of ACE inhibitors in reducing proteinuria 

• Breaking down a test question on nephrotic syndrome treatment 

This episode is packed with high-yield information to help you understand nephrotic syndrome from both a pathophysiological and clinical perspective. Tune in now!

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