RadOnc Smart Review

RadOnc Smart Review

AI Generated Podcast reviewing various topics in Radiation Oncology for Residents on the go.

Episodes

RadBio E22A: Chemo+RT - Principles & Drug Classes.

May 22, 2025 • 19 mins
This is Episode 22, Part A: Chemo+RT - Principles & Drug Classes.For decades, radiation therapy has been a cornerstone of cancer treatment, offering potent local control. But as we know, cancer can be a systemic disease, and sometimes radiation alone isn't enough, or we want to make its local effects even more powerful. That’s where combining it with chemotherapy comes into play. Today, we're going to lay the foundational princ...
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RadBio E21B: Advanced Modalities - IMRT & FLASH

May 22, 2025 • 25 mins
This is Episode 21, Part B: Advanced Modalities - IMRT & FLASH.In our previous episode, we explored the exciting world of particle therapy, looking at how protons and heavy ions like carbon aim to improve treatment by precisely targeting tumors. Today, we continue our journey into advanced radiotherapy modalities, but we’ll shift our focus back to photon-based treatments and a very novel high-dose-rate concept. First, we'll dis...
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RadBio E21A: Advanced Modalities - Particle Therapy.

May 22, 2025 • 16 mins
This is Episode 21, Part A: Advanced Modalities - Particle Therapy.In our previous episodes, we've explored the radiobiology of conventional photon therapy, including fractionation and dose rate effects, and we've touched on brachytherapy. Today, we're venturing into the realm of particle therapy, focusing on charged particles like protons and heavier ions, particularly carbon ions. These modalities offer distinct physical and biol...
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Physics Episode P20: Brachytherapy Radiobiology

May 22, 2025 • 21 mins
Welcome back to Rad Onc Smart Review, Radiation Biology edition is Episode 20: Brachytherapy Radiobiology. In our previous discussions, we've explored the principles of fractionation, primarily in the context of external beam radiotherapy, where doses are delivered in discrete, short bursts. Today, we're shifting gears to a fascinating and very different world of radiation delivery: brachytherapy. The term "brachy" comes from the G...
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RadBio E19: Altered Fractionation - Hyperfractionation, Accelerated Radiotherapy, and CHART

May 22, 2025 • 23 mins
This is Episode 19: Altered Fractionation - Hyperfractionation, Accelerated Radiotherapy, and CHART.In our previous episode, we mastered the Linear-Quadratic model and the concept of Biological Effective Dose, tools that allow us to compare different radiation schedules. We learned that early and late-responding tissues, as well as tumors, have different sensitivities to changes in fraction size, largely dictated by their α/β ratio...
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RadBio E18C: Fractionation - The LQ Model, BED, and Isoeffect Curves

May 22, 2025 • 21 mins
This is Episode 18, Part C: Fractionation - The LQ Model, BED, and Isoeffect Curves.In our previous discussions on fractionation, we’ve explored the "4 R's" and the impact of dose rate. These concepts help explain why fractionated radiotherapy works. Now, we need a way to quantify these effects and compare different fractionation schedules. This is where the Linear-Quadratic, or LQ, model comes into play. Today, we'll revisit the L...
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RadBio E18B: Fractionation - Dose Rate Effects

May 22, 2025 • 16 mins
This is Episode 18, Part B: Fractionation - Dose Rate Effects.In our last episode, we laid the groundwork by exploring the "Four Rs of Radiobiology" – Repair, Reassortment, Repopulation, and Reoxygenation – which explain the benefits of delivering radiation in multiple fractions. Today, we're going to zoom in on another critical parameter that profoundly influences biological outcome: the dose rate, or how quickly a given dose of r...
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RadBio E18A:Fractionation - The Four Rs of Radiobiology

May 22, 2025 • 18 mins
This is Episode 18, Part A: Fractionation - The Four Rs of Radiobiology.In our last episode, we discussed the therapeutic ratio and the ongoing quest to predict how tumors and normal tissues will respond to radiation. One of the oldest and still most powerful strategies we use to widen this therapeutic window – to maximize tumor kill while minimizing normal tissue damage – is fractionation. That means instead of giving one massive ...
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Physics Episode E17: Therapeutic Ratio & Predictive Assays

May 22, 2025 • 30 mins
This is Episode 17: Therapeutic Ratio & Predictive Assays. In our previous episodes, we've explored how radiation interacts with cells and tissues, the different types of damage it causes, and how cells attempt to repair that damage. We've also seen that different tissues, both normal and malignant, respond differently to radiation. The ultimate goal in radiation therapy is to deliver a dose that is high enough to eradicate all...
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RadBio E16: Normal Tissue Mechanisms: Functional Subunits, Cytokines, and Fibrosis

May 21, 2025 • 24 mins
This is Episode 16: Normal Tissue Mechanisms: Functional Subunits, Cytokines, and Fibrosis.In our previous episodes covering normal tissue effects, we've seen how different organs respond to radiation over various timescales, manifesting as either early or late toxicities. We've also touched upon the idea that the structure and organization of a tissue, along with complex cellular signaling, profoundly influence these responses. To...
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RadBio E15D: Normal Tissues - Late Effects on Gonads and Bone.

May 21, 2025 • 17 mins
This is Episode 15, Part D: Normal Tissues - Late Effects on Gonads and Bone.In our previous episodes, we've explored the late detrimental effects of radiation on critical organs like the central nervous system, lungs, heart, and kidneys. Today, we turn our attention to two other vital tissue systems that can suffer long-term consequences from radiation exposure: the gonads – testes and ovaries – and bone, distinguishing between it...
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RadBio E15C: Normal Tissues - Late Effects (Heart, Kidney, and Lens)

May 21, 2025 • 24 mins
This is Episode 15, Part C: Normal Tissues - Late Effects (Heart, Kidney, and Lens).In our previous episode, we discussed the late effects of radiation on the central nervous system and the lungs. Today, we continue our exploration of late normal tissue toxicities by focusing on three more critical organs: the heart, the kidneys, and the lens of the eye. These organs, while perhaps not always dose-limiting in the same way as the sp...
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RadBio E15B:Normal Tissues - Late Effects, focusing on the Central Nervous System and Lungs.

May 21, 2025 • 23 mins
In our previous episode, we explored the acute, or early, effects of radiation on rapidly dividing normal tissues like the skin, gut, and bone marrow. These effects, while often distressing, are typically transient and heal. Today, we shift our attention to a different category of radiation injury: late effects. These complications can manifest months or even years after the completion of radiotherapy and are often progressive and ...
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RadBio E15A: Normal Tissues - Early Effects on Skin, Gut, and Bone Marrow.

May 21, 2025 • 20 mins
In our last episode, we discussed the dramatic and often devastating consequences of Total Body Irradiation, focusing on the acute radiation syndromes. Today, we're narrowing our focus to the specific early, or acute, effects of radiation on some of the most critical rapidly renewing normal tissues: the skin, the gastrointestinal tract, often called the G I tract, and the hematopoietic system, often referred to as bone marrow. Thes...
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RadBio E14: Total Body Irradiation (TBI) Syndromes.

May 21, 2025 • 16 mins
This is Episode 14, Total Body Irradiation (TBI) Syndromes. Today, we're shifting our focus from the cellular level to the effects of radiation on the whole organism, specifically when the entire body is exposed to a significant dose of radiation. This can happen in radiation accidents, nuclear incidents, or unfortunately, in scenarios involving radiological terrorism, but also, in a controlled manner, during conditioning regimens ...
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RadBio E13D: Cancer Biology - Hallmarks & Telomeres

May 19, 2025 • 16 mins
Welcome back to Rad Onc Smart Review, the podcast that simplifies the science behind cancer treatment. This is Episode 13 Part D, Cancer Biology - Hallmarks & Telomeres. In our previous cancer biology segments, we've explored the individual components: oncogenes, tumor suppressor genes, and the critical signaling pathways they control. Today, we're going to take a broader view, looking at the common capabilities that most, if n...
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RadBio E13C: Cancer Biology - Signaling: EGFR, Ras, PI3K, Myc, and NF-κB.

May 19, 2025 • 23 mins
This is Episode 13 Part C, Cancer Biology - Signaling: EGFR, Ras, PI3K, Myc, and NF-κB.In our previous episodes on cancer biology, we've explored oncogenes – the cellular accelerators – and tumor suppressor genes – the cellular brakes. Today, we're going to connect these concepts by diving into the intricate communication networks within cells: the signaling pathways. These pathways dictate how cells respond to their environment, w...
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RadBio E13B: Repair Over Time: SLD, PLD & Dose Rate TTS

May 19, 2025 • 24 mins
Welcome back to Rad Onc Smart Review, the podcast dedicated to helping you master the core concepts of radiation oncology and radiobiology. This is Episode 13 Part B, Cancer Biology - Tumor Suppressor Genes .In our previous episode, we delved into the world of oncogenes, the "gas pedals" of the cell that, when stuck, can drive cancer. Today, we're turning our attention to the other side of the coin: Tumor Suppressor Genes, or TSGs....
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RadBio E13A: Cancer Biology - Oncogenes

May 19, 2025 • 20 mins
Welcome back to Rad Onc Smart Review, the podcast dedicated to helping you master the core concepts of radiation oncology and radiobiology. This is Episode 13 Part A, Cancer Biology - Oncogenes.In our previous episodes, we've explored the intricacies of how radiation interacts with cells, the resulting damage and repair processes, and how cell populations, both normal and malignant, respond kinetically. Now, we begin a new chapter,...
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RadBio E12B:Tumor Kinetics - Tpot, GF & Cell Loss

May 19, 2025 • 16 mins
Welcome back to Rad Onc Smart Review, your go-to podcast for mastering the core concepts of radiation oncology and radiobiology. This is Episode 12 Part B, Tumor Kinetics - Tpot, GF & Cell Loss. In our previous episode, P12a, we laid the groundwork by exploring the phases of the cell cycle, how radiosensitivity varies within them, and the techniques used to measure cell cycle parameters, like Percent Labeled Mitoses and Flow Cy...
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